Si Qingying, Sun Wenxue, Liang Benhui, Chen Beibei, Meng Junjun, Xie Dadi, Feng Lei, Jiang Pei
Department of Endocrinology, Tengzhou Central People's Hospital, Tengzhou, 277599, People's Republic of China.
Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, People's Republic of China.
Adv Biol (Weinh). 2024 Feb;8(2):e2300413. doi: 10.1002/adbi.202300413. Epub 2023 Oct 25.
Adequate sleep is essential for the biological maintenance of physical energy. Lack of sleep can affect thinking, lead to emotional anxiety, reduce immunity, and interfere with endocrine and metabolic processes, leading to disease. Previous studies have focused on long-term sleep deprivation and the risk of cancer, heart disease, diabetes, and obesity. However, systematic metabolomics analyses of blood, heart, liver, spleen, kidney, brown adipose tissue, and fecal granules have not been performed. This study aims to systematically assess the metabolic changes in the target organs caused by sleep deprivation in vivo, to search for differential metabolites and the involved metabolic pathways, to further understand the impact of sleep deprivation on health, and to provide strong evidence for the need for early intervention.
充足的睡眠对于身体能量的生物维持至关重要。睡眠不足会影响思维，导致情绪焦虑，降低免疫力，并干扰内分泌和代谢过程，进而引发疾病。以往的研究主要关注长期睡眠剥夺以及患癌症、心脏病、糖尿病和肥胖症的风险。然而，尚未对血液、心脏、肝脏、脾脏、肾脏、棕色脂肪组织和粪便颗粒进行系统的代谢组学分析。本研究旨在系统评估体内睡眠剥夺引起的靶器官代谢变化，寻找差异代谢物及相关代谢途径，进一步了解睡眠剥夺对健康的影响，并为早期干预的必要性提供有力证据。
