Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Goldenfelsstr, Cologne, Germany.
German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
mBio. 2023 Dec 19;14(6):e0226023. doi: 10.1128/mbio.02260-23. Epub 2023 Oct 26.
Carbapenem-resistant are of increasing public health importance, as they are resistant to last-line antibiotics. International clones with well-characterized resistance genes dominate globally; however, locally, other lineages with different properties may be of importance to consider. This study investigated isolates from a broad geographic origin from 114 hospitals in 47 countries and from five world regions ensuring the greatest possible diversity in an organism known for its propensity for clonal epidemic spread and reflecting the current global epidemiology of carbapenem-resistant . In Latin America, a lineage different from other geographic regions circulates, with a different resistance gene profile. This knowledge is important to adjust local infection prevention measures. In a global world with migration and increasing use of antimicrobials, multidrug-resistant bacteria will continue to adapt and challenge our healthcare systems worldwide.
耐碳青霉烯肠杆菌对公共卫生的重要性日益增加，因为它们对最后一线抗生素具有耐药性。具有明确耐药基因的国际克隆在全球占主导地位；然而，在当地，具有不同特性的其他谱系可能需要考虑。本研究调查了来自 47 个国家 114 家医院的广泛地理来源的分离株，来自五个世界区域，以确保在已知具有克隆流行传播倾向的生物体中具有最大的多样性，并反映当前全球耐碳青霉烯肠杆菌的流行病学。在拉丁美洲，一种与其他地理区域不同的谱系在传播，其耐药基因谱不同。了解这一点对于调整当地的感染预防措施很重要。在一个全球化的世界中，随着移民和抗生素使用的增加，多药耐药菌将继续适应并挑战我们全球的医疗保健系统。
Zotero 插件
