孤啡肽/强啡肽 FQ 受体部分激动剂 sunobinop 可促进啮齿动物和失眠患者的非快速动眼睡眠。
The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia.
机构信息
Imbrium Therapeutics, Stamford, Connecticut, USA.
Purdue Pharma LP, Stamford, Connecticut, USA.
出版信息
J Clin Invest. 2024 Jan 2;134(1):e171172. doi: 10.1172/JCI171172.
Abstract
The potent and partial agonist sunobinop activates the nociceptin/orphanin-FQ peptide receptor and promotes non-REM sleep in rodents and patients with insomnia.
摘要
强效部分激动剂苏诺因激活孤啡肽/强啡肽 FQ 肽受体，并促进啮齿动物和失眠患者的非快速动眼睡眠。
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