Altern Ther Health Med. 2024 Feb;30(2):90-96.
This work assessed the impact of drug therapy combined with pulmonary rehabilitation exercise training on specific lung function and respiratory parameters of lung cancer (LC) patients after thoracoscopic lobectomy.
88 LC patients who had undergone thoracoscopic lobectomy were selected based on their surgical indications and health condition. The study aimed to explore methods to assist patients in their postoperative recovery; therefore, patients meeting the surgical criteria were chosen to ensure the internal validity and external applicability of the results. Meanwhile, these 88 LC patients undergoing thoracoscopic lobectomy were randomly allocated into an experimental group (EG, 44 cases) and a control group (CG, 44 cases). The EG received inhalation therapy with albuterol sulfate nebulizer solution and personalized pulmonary rehabilitation exercise training, while the CG received nebulized treatment alone. The study lasted for three months. The pulmonary rehabilitation program included regular physical exercises, including respiratory training and physical fitness training, among other activities.
After pulmonary lobectomy surgery, both groups of patients showed a significant decrease in (1) forced vital capacity (FVC), (2) forced expiratory volume in 1 second (FEV1), (3) maximum voluntary ventilation (MVV), and (4) peak expiratory flow (PEF). However, the values of FVC, FEV1, MVV, and PEF in the EG were significantly higher than those in the CG (P < .05). Furthermore, both groups demonstrated significant improvements in the 6-minute walk test (6MWT) results after lung lobectomy; however, the 6MWT results in the EG also significantly increased (P < .05). In terms of dyspnea index (DI), after lung lobectomy, the DI for both groups of patients significantly increased, but the DI in the EG was significantly lower than that in the CG (P < .05).
The combined application of drug therapy and pulmonary rehabilitation exercise training contributed to promoting cardiopulmonary function and respiratory muscle recovery in LC patients after thoracoscopic lobectomy. This was crucial for improving the quality of life of patients, as enhanced cardiopulmonary function and respiratory muscle recovery can alleviate postoperative respiratory difficulties, increase the physical stamina and activity levels of patients. This may help reduce the risk of postoperative complications, shorten hospital stays, and potentially improve long-term survival rates. Consequently, these results could have a positive impact on the development of postoperative care and treatment strategies. However, this work was subjected to several limitations, including a relatively short duration, necessitating longer-term follow-up to assess long-term effects. Additionally, the sample size was relatively small, and further large-scale research was needed to validate these findings.
本研究旨在评估药物治疗联合肺康复运动训练对胸腔镜肺叶切除术后肺癌（LC）患者特定肺功能和呼吸参数的影响。
根据手术适应证和健康状况，选择 88 例接受胸腔镜肺叶切除术的 LC 患者。本研究旨在探讨辅助患者术后康复的方法；因此，选择符合手术标准的患者，以确保研究结果的内部有效性和外部适用性。同时，将这 88 例接受胸腔镜肺叶切除术的 LC 患者随机分为实验组（EG，44 例）和对照组（CG，44 例）。EG 接受硫酸沙丁胺醇雾化吸入治疗和个性化肺康复运动训练，而 CG 仅接受雾化治疗。研究持续三个月。肺康复计划包括定期体育锻炼，包括呼吸训练和体能训练等活动。
肺叶切除术后，两组患者（1）用力肺活量（FVC）、（2）第 1 秒用力呼气量（FEV1）、（3）最大自主通气量（MVV）和（4）呼气峰流量（PEF）均显著下降。然而，EG 组的 FVC、FEV1、MVV 和 PEF 值明显高于 CG 组（P <.05）。此外，两组患者在肺叶切除术后 6 分钟步行试验（6MWT）结果均有显著改善，但 EG 组的 6MWT 结果也显著增加（P <.05）。在呼吸困难指数（DI）方面，肺叶切除术后，两组患者的 DI 均显著增加，但 EG 组的 DI 明显低于 CG 组（P <.05）。
药物治疗联合肺康复运动训练有助于促进胸腔镜肺叶切除术后 LC 患者心肺功能和呼吸肌恢复。这对于提高患者的生活质量至关重要，因为增强心肺功能和呼吸肌恢复可以减轻术后呼吸困难，增加患者的体力和活动水平。这可能有助于降低术后并发症的风险，缩短住院时间，并可能提高长期生存率。因此，这些结果可能对术后护理和治疗策略的发展产生积极影响。然而，本研究受到了一些限制，包括研究持续时间相对较短，需要进行更长时间的随访以评估长期效果。此外，样本量相对较小，需要进一步进行大规模研究来验证这些发现。
