Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznań, Poland.
Cutaneous Histopathology and Immunopathology Section, Poznan University of Medical Sciences, Poznań, Poland.
Front Immunol. 2023 Oct 10;14:1227855. doi: 10.3389/fimmu.2023.1227855. eCollection 2023.
The involvement of palms and soles is variable among disease entities belonging to autoimmune bullous diseases (AIBD). We present our own clinical-laboratory experience concerning presentations of skin lesions on palms and soles in the pemphigus diseases group, pemphigoid diseases group, epidermolysis bullosa acquisita (EBA), and lichen planus pemphigoides (LPP) and discuss the pertinent literature.
Lesions on palms and soles were assessed retrospectively on the basis of just photographic archives from the beginning of 2014 to March 2023. We comparatively evaluated 462 Slavic patients with AIBD.
Palmoplantar involvement was observed in only 21 patients with AIBD (12 females and 9 males). There was no statistically significant difference between palmoplantar involvement in the pemphigus diseases group compared to the pemphigoid diseases group and no statistically significant difference between the pemphigus diseases group compared to the subepithelial AIBD.
Nevertheless, particularly in LPP and EBA, and occasionally in pemphigus diseases and pemphigoid diseases groups of AIBD, localization on palms and soles may be diagnostically important at the clinical level.
在自身免疫性大疱性疾病（AIBD）所属的各种疾病实体中，手掌和足底受累情况各不相同。我们介绍了自身在大疱性类天疱疮、天疱疮、获得性大疱性表皮松解症和扁平苔藓天疱疮这 4 种疾病组中，皮损累及手掌和足底的临床-实验室经验，并讨论了相关文献。
我们根据 2014 年初至 2023 年 3 月的照片档案，对仅累及手掌和足底的病变进行回顾性评估。我们比较性地评估了 462 例斯拉夫裔 AIBD 患者。
AIBD 患者中仅有 21 例（12 例女性，9 例男性）出现手掌和足底受累。与大疱性类天疱疮组相比，天疱疮组手掌和足底受累并无统计学差异，与黏膜下 AIBD 相比，天疱疮组手掌和足底受累也无统计学差异。
然而，在扁平苔藓天疱疮和获得性大疱性表皮松解症中，尤其在偶尔出现于天疱疮和大疱性类天疱疮组的情况下，手掌和足底的定位在临床层面可能具有重要的诊断意义。
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