Erhardt L
Acta Pharmacol Toxicol (Copenh). 1986;59 Suppl 6:129-32. doi: 10.1111/j.1600-0773.1986.tb02558.x.
The development of tolerance to the effects of nitrates is well documented in the literature. It can be induced and rapidly reversed with all types of nitrates and it is more pronounced in the arterial as compared to the venous circulation. Cross-tolerance between different nitrates exists. Furthermore, tolerance seems more related to high and continuous plasma concentrations and may possibly be avoided by intermittent dosing. The importance of such factors as patient selection, type of nitrate preparation, duration of therapy, the significance of target organs, methods of evaluating the development of nitrate tolerance as well as a summary of the discussions during the workshop is presented.
文献中对硝酸盐作用耐受性的发展已有充分记载。所有类型的硝酸盐均可诱导产生耐受性，且能迅速逆转，与静脉循环相比，在动脉循环中耐受性更为明显。不同硝酸盐之间存在交叉耐受性。此外，耐受性似乎与高且持续的血浆浓度更为相关，间歇给药可能避免耐受性的产生。本文介绍了诸如患者选择、硝酸盐制剂类型、治疗持续时间、靶器官的重要性、评估硝酸盐耐受性发展的方法等因素的重要性，以及研讨会期间的讨论总结。
