Department of Neuro-oncology, Princess Máxima Center, Utrecht, Netherlands.
Department of Neurosurgery, University of Amsterdam, Amsterdam University Medical Center (UMC), Amsterdam, Netherlands.
Front Endocrinol (Lausanne). 2023 Oct 11;14:1225734. doi: 10.3389/fendo.2023.1225734. eCollection 2023.
We present the case of a 15-year-old girl, with a fifth cystic progression of an adamantinomatous craniopharyngioma after multiple surgeries and previous local radiotherapy. She had severe visual impairment, panhypopituitarism including diabetes insipidus, and several components of hypothalamic damage, including morbid obesity and severe fatigue. To prevent further late effects hampering her quality of survival, she was treated biweekly with intravenous tocilizumab, an anti-interleukin-6 agent, which stabilized the cyst for a prolonged time. Based on the biology of adamantinomatous craniopharyngioma, this immune-modulating treatment seems promising for the treatment of this cystic tumor in order to reduce surgery and delay or omit radiotherapy.
我们报告了一例 15 岁女孩的病例，她在多次手术后和先前的局部放疗后，第五次出现颅咽管瘤囊变。她有严重的视力障碍、全垂体功能减退症，包括尿崩症，以及下丘脑损伤的几个部分，包括病态肥胖和严重疲劳。为了防止进一步的晚期影响妨碍她的生存质量，她每两周接受一次静脉注射托珠单抗（一种抗白细胞介素-6 药物）治疗，这使囊肿长时间稳定。基于颅咽管瘤的生物学特性，这种免疫调节治疗对于治疗这种囊性肿瘤似乎很有前景，可以减少手术次数，并延迟或避免放疗。
