质谱分析法在肝细胞癌生物标志物发现中的作用
The Role of Mass Spectrometry in Hepatocellular Carcinoma Biomarker Discovery.
作者信息
Shen Eric Yi-Liang, U Mei Ran Abellona, Cox I Jane, Taylor-Robinson Simon D
机构信息
Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City 333, Taiwan.
Clinical Metabolomics Core Laboratory, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City 333, Taiwan.
出版信息
Metabolites. 2023 Oct 8;13(10):1059. doi: 10.3390/metabo13101059.
Hepatocellular carcinoma (HCC) is the main liver malignancy and has a high mortality rate. The discovery of novel biomarkers for early diagnosis, prognosis, and stratification purposes has the potential to alleviate its disease burden. Mass spectrometry (MS) is one of the principal technologies used in metabolomics, with different experimental methods and machine types for different phases of the biomarker discovery process. Here, we review why MS applications are useful for liver cancer, explain the MS technique, and briefly summarise recent findings from metabolomic MS studies on HCC. We also discuss the current challenges and the direction for future research.
肝细胞癌（HCC）是主要的肝脏恶性肿瘤，死亡率很高。发现用于早期诊断、预后评估和分层的新型生物标志物有可能减轻其疾病负担。质谱（MS）是代谢组学中使用的主要技术之一，在生物标志物发现过程的不同阶段有不同的实验方法和仪器类型。在此，我们综述了为什么MS应用对肝癌有用，解释了MS技术，并简要总结了肝癌代谢组学MS研究的近期发现。我们还讨论了当前的挑战和未来的研究方向。
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