硒化合物对两种细胞因子风暴参与者的选择性影响。
Selective Impact of Selenium Compounds on Two Cytokine Storm Players.
作者信息
Sinha Indu, Zhu Junjia, Sinha Raghu
机构信息
Department of Biochemistry and Molecular Biology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
Department of Public Health Sciences, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
出版信息
J Pers Med. 2023 Sep 30;13(10):1455. doi: 10.3390/jpm13101455.
COVID-19 patients suffer from the detrimental effects of cytokine storm and not much success has been achieved to overcome this issue. We sought to test the ability of selenium to reduce the impact of two important cytokine storm players: IL-6 and TNF-α. The effects of four selenium compounds on the secretion of these cytokines from THP-1 macrophages were evaluated in vitro following an LPS challenge. Also, the potential impact of methylseleninic acid (MSeA) on Nrf2 and IκBα was determined after a short treatment of THP-1 macrophages. MSeA was found to be the most potent selenium form among the four selenium compounds tested that reduced the levels of IL-6 and TNF-α secreted by THP-1 macrophages. In addition, an increase in Nrf2 and decrease in pIκBα in human macrophages was observed following MSeA treatment. Our data indicate that COVID-19 patients might benefit from the addition of MSeA to the standard therapy due to its ability to suppress the key players in the cytokine storm.
新冠肺炎患者遭受细胞因子风暴的有害影响，在克服这一问题上尚未取得太大成功。我们试图测试硒降低两种重要细胞因子风暴参与者白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）影响的能力。在脂多糖（LPS）刺激后，体外评估了四种硒化合物对THP-1巨噬细胞分泌这些细胞因子的影响。此外，在对THP-1巨噬细胞进行短期处理后，确定了甲基亚硒酸（MSeA）对核因子E2相关因子2（Nrf2）和核因子κB抑制蛋白α（IκBα）的潜在影响。在测试的四种硒化合物中，MSeA被发现是最有效的硒形式，它降低了THP-1巨噬细胞分泌的IL-6和TNF-α水平。此外，在MSeA处理后，观察到人类巨噬细胞中Nrf2增加，磷酸化IκBα（pIκBα）减少。我们的数据表明，新冠肺炎患者可能会从在标准治疗中添加MSeA中受益，因为它有能力抑制细胞因子风暴中的关键参与者。
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