Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Russia.
Int J Mol Sci. 2022 Feb 21;23(4):2360. doi: 10.3390/ijms23042360.
The review presents the latest data on the role of selenium-containing agents in the regulation of diseases of the immune system. We mainly considered the contributions of selenium-containing compounds such as sodium selenite, methylseleninic acid, selenomethionine, and methylselenocysteine, as well as selenoproteins and selenium nanoparticles in the regulation of defense mechanisms against various viral infections, including coronavirus infection (COVID-19). A complete description of the available data for each of the above selenium compounds and the mechanisms underlying the regulation of immune processes with the active participation of these selenium agents, as well as their therapeutic and pharmacological potential, is presented. The main purpose of this review is to systematize the available information, supplemented by data obtained in our laboratory, on the important role of selenium compounds in all of these processes. In addition, the presented information makes it possible to understand the key differences in the mechanisms of action of these compounds, depending on their chemical and physical properties, which is important for obtaining a holistic picture and prospects for creating drugs based on them.
该综述介绍了含硒试剂在调节免疫系统疾病中的最新数据。我们主要考虑了含硒化合物（如亚硒酸钠、甲基硒酸、硒代蛋氨酸和甲基硒代半胱氨酸）以及硒蛋白和硒纳米粒子在调节针对各种病毒感染（包括冠状病毒感染（COVID-19））的防御机制方面的贡献。本文完整描述了上述每种硒化合物的现有数据，以及这些硒试剂通过积极参与调节免疫过程的机制，以及它们的治疗和药理学潜力。本综述的主要目的是系统化现有信息，补充我们实验室获得的数据，说明硒化合物在所有这些过程中的重要作用。此外，所提供的信息使人们能够了解这些化合物作用机制的关键差异，这取决于它们的化学和物理性质，这对于获得整体图景和基于它们创造药物的前景非常重要。
