药物干预对接受药物治疗的高血压患者的影响——一项整群随机临床试验：AFPRES-CLM研究
Effect of Pharmaceutical Intervention in Pharmacologically Treated Hypertensive Patients-A Cluster-Randomized Clinical Trial: AFPRES-CLM Study.
作者信息
Luque Del Moral Raúl, Gastelurrutia Miguel A, Martinez-Martinez Fernando, Jacomé Julio A, Dago Ana, Suarez Blanca, Fikri-Benbrahim Narjis, Martí Mercé, Nuñez Cristina, Sierra-Alarcón Sandra, Fernandez-Gomez Francisco-José
机构信息
Pharmaceutical Care Research Group, University of Granada, 18011 Granada, Spain.
Council of Official Associations of Pharmaceutics of Castilla-La Mancha, 45005 Toledo, Spain.
出版信息
J Pers Med. 2023 Oct 11;13(10):1484. doi: 10.3390/jpm13101484.
BACKGROUND
Evaluate the effect of a community pharmaceutical intervention on the control of blood pressure in hypertensive patients treated pharmacologically.
METHODS
A cluster-randomized clinical trial of 6 months was carried out. It was conducted in the Autonomous Community of Castilla-La Mancha (Spain). Sixty-three community pharmacies and 347 patients completed the study. Intervention patients received the community pharmaceutical intervention based on a protocol that addresses the individual needs of each patient related to the control of their blood pressure, which included Health Education, Pharmacotherapy Follow-up and 24 h Ambulatory Blood Pressure Measurement. Control patients received usual care in the community pharmacy.
RESULTS
The pharmaceutical intervention resulted in better control of blood pressure (85.8% vs. 66.3% < 0.001), lower use of emergencies ( = 0.002) and improvement trends in the physical components of quality of life, measured by SF-36 questionnaire, after 6 months of pharmaceutical intervention. No significant changes were observed for any of these variables in the control group. There were also detected 354 negative medication-related outcomes that were satisfactorily resolved in a 74.9% of the cases and 330 healthcare education interventions and 29 Ambulatory Blood Pressure Monitorings were performed in order to increase adherence to pharmacological treatment and minimize Negative Outcomes associated with Medication and prevent medication-related problems.
CONCLUSIONS
Community pharmaceutical intervention can increase hypertensive patients with controlled blood pressure, after 6 months, compared with usual care.
背景
评估社区药学干预对接受药物治疗的高血压患者血压控制的效果。
方法
开展了一项为期6个月的整群随机临床试验。该试验在西班牙卡斯蒂利亚-拉曼恰自治区进行。63家社区药房和347名患者完成了研究。干预组患者接受基于针对每位患者血压控制个体需求的方案的社区药学干预，该方案包括健康教育、药物治疗随访和24小时动态血压测量。对照组患者在社区药房接受常规护理。
结果
经过6个月的药学干预后，药学干预使血压得到更好的控制（85.8% 对66.3%，P<0.001），急诊使用减少（P = 0.002），并且通过SF-36问卷测量的生活质量身体成分有改善趋势。对照组在这些变量中均未观察到显著变化。还检测到354个与药物相关的负面结果，其中74.9%的案例得到了满意解决，并且进行了330次医疗保健教育干预和29次动态血压监测，以提高药物治疗依从性，最大限度减少与药物相关的负面结果并预防药物相关问题。
结论
与常规护理相比，社区药学干预在6个月后可增加血压得到控制的高血压患者数量。
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