Nidey Nichole, Bowers Katherine, Ding Lili, Ji Hong, Ammerman Robert T, Yolton Kimberly, Mahabee-Gittens E Melinda, Folger Alonzo T
Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA.
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Toxics. 2023 Oct 13;11(10):855. doi: 10.3390/toxics11100855.
(1) Introduction: Epigenetic changes have been proposed as a biologic link between in-utero exposure to maternal smoking and health outcomes. Therefore, we examined if in-utero exposure to maternal smoking was associated with infant DNA methylation (DNAm) of cytosine-phosphate-guanine dinucleotides (CpG sites) in the arginine vasopressin receptor 1A gene. The gene encodes a receptor that interacts with the arginine vasopressin hormone and may influence physiological stress regulation, blood pressure, and child development. (2) Methods: Fifty-two infants were included in this cohort study. Multivariable linear models were used to examine the effect of in-utero exposure to maternal smoking on the mean DNAm of CpG sites located at (3) Results: After adjusting the model for substance use, infants with in-utero exposure to maternal smoking had a reduction in DNAm at CpG sites by -0.02 (95% CI -0.03, -0.01) at one month of age. In conclusion, in-utero exposure to tobacco smoke can lead to differential patterns of DNAm of among infants. Conclusions: Future studies are needed to identify how gene expression in response to early environmental exposures contributes to health outcomes.
(1) 引言：表观遗传变化被认为是子宫内暴露于母亲吸烟与健康结果之间的生物学联系。因此，我们研究了子宫内暴露于母亲吸烟是否与精氨酸加压素受体1A基因中胞嘧啶-磷酸-鸟嘌呤二核苷酸（CpG位点）的婴儿DNA甲基化（DNAm）有关。该基因编码一种与精氨酸加压素激素相互作用的受体，可能影响生理应激调节、血压和儿童发育。(2) 方法：本队列研究纳入了52名婴儿。使用多变量线性模型来研究子宫内暴露于母亲吸烟对位于……处CpG位点平均DNAm的影响。(3) 结果：在对物质使用情况调整模型后，子宫内暴露于母亲吸烟的婴儿在1个月大时，CpG位点的DNAm降低了-0.02（95%置信区间为-0.03，-0.01）。总之，子宫内暴露于烟草烟雾可导致婴儿中……的DNAm出现差异模式。结论：未来需要开展研究，以确定早期环境暴露后的基因表达如何影响健康结果。
