Department of Medical Microbiology, University Medical Center Utrecht , Utrecht, the Netherlands.
Mahidol Oxford Tropical Medicine Research Unit (MORU) , Bangkok, Thailand.
Microbiol Spectr. 2023 Dec 12;11(6):e0127523. doi: 10.1128/spectrum.01275-23. Epub 2023 Oct 27.
Colonization with extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) often precedes infections and is therefore considered as a great threat for public health. Here, we studied the gut microbiome dynamics in eight index patients colonized with ESBL-PE after hospital discharge and the impact of exposure to this index patient on the gut microbiome dynamics of their household contacts. We showed that the microbiome composition from index patients is different from their household contacts upon hospital discharge and that, in some of the index patients, their microbiome composition over time shifted toward the composition of their household contacts. In contrast, household contacts showed a stable microbiome composition over time irrespective of low-level extended-spectrum beta-lactamase-producing (ESBL-Ec) or extended-spectrum beta-lactamase-producing (ESBL-Kp) gut colonization, suggesting that, in healthy microbiomes, colonization resistance is able to prevent ESBL-PE expansion.
产超广谱β-内酰胺酶肠杆菌科（ESBL-PE）定植通常先于感染发生，因此被认为对公共健康构成重大威胁。在这里，我们研究了 8 位出院后定植 ESBL-PE 的指数患者的肠道微生物组动态，以及接触这些指数患者对其家庭接触者肠道微生物组动态的影响。我们表明，出院时，指数患者的微生物组组成与他们的家庭接触者不同，并且在一些指数患者中，他们的微生物组组成随时间推移向其家庭接触者的组成转移。相比之下，家庭接触者无论是否存在低水平的产超广谱β-内酰胺酶肠杆菌科（ESBL-Ec）或产超广谱β-内酰胺酶肺炎克雷伯菌（ESBL-Kp）肠道定植，其微生物组组成随时间保持稳定，这表明在健康的微生物组中，定植抵抗能够防止 ESBL-PE 扩张。
