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通过双重铜催化的C-N偶联反应轻松获得5-噻唑并[2',3':2,3]咪唑并[4,5-]吲哚衍生物。

Facile access to 5-thiazolo[2',3':2,3]imidazo[4,5-]indole derivatives by two-fold Cu-catalysed C-N coupling reactions.

作者信息

Hung Tran Quang, Nguyen Bao Chi Quang, Phuc Ban Van, Dang Van Tien Dat, Trang Chu Mai, Anh Quang Thi Kim, Do Dang Van, Nguyen Hien, Ngo Quoc Anh, Dang Tuan Thanh

机构信息

Institute of Chemistry, Vietnam Academy of Science and Technology, Viet Nam.

Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Viet Nam.

出版信息

Org Biomol Chem. 2023 Nov 15;21(44):8813-8818. doi: 10.1039/d3ob01515g.

DOI:10.1039/d3ob01515g
PMID:37889185
Abstract

In four simple steps, a series of 5-thiazolo[2',3':2,3]imidazo[4,5-]indole and 11-benzo[4',5']thiazolo[2',3':2,3]imidazo[4,5-]indole derivatives were prepared with high yields. The key step in this procedure was demonstrated to be two-fold Cu-catalysed C-N coupling reactions of 5-bromo-6-(2-bromophenyl)imidazo[2,1-]thiazole and 3-bromo-2-(2-bromophenyl)benzo[]imidazo[2,1-]thiazole with various amines.

摘要

通过四个简单步骤，高产率地制备了一系列5-噻唑并[2',3':2,3]咪唑并[4,5-]吲哚和11-苯并[4',5']噻唑并[2',3':2,3]咪唑并[4,5-]吲哚衍生物。该方法的关键步骤被证明是5-溴-6-(2-溴苯基)咪唑并[2,1-]噻唑和3-溴-2-(2-溴苯基)苯并[]咪唑并[2,1-]噻唑与各种胺的两步铜催化C-N偶联反应。

相似文献

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Facile access to 5-thiazolo[2',3':2,3]imidazo[4,5-]indole derivatives by two-fold Cu-catalysed C-N coupling reactions.通过双重铜催化的C-N偶联反应轻松获得5-噻唑并[2',3':2,3]咪唑并[4,5-]吲哚衍生物。
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