肠道微生物组作为 HIV 感染者肛门癌前病变的生物标志物。
The microbiome as a biomarker of anal precancerous lesions in people with HIV.
机构信息
Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Madrid, Spain, CIBERINFEC.
出版信息
Curr Opin Infect Dis. 2024 Feb 1;37(1):17-25. doi: 10.1097/QCO.0000000000000985. Epub 2023 Oct 27.
PURPOSE OF REVIEW
Early detection and treatment of human papillomavirus (HPV)-related anal dysplasia in some high-risk groups can help anal cancer prevention, but new tools to improve diagnostic and risk assessment are needed. Here, we aim to discuss the evidence on the role of the microbiome as a potential biomarker for anal high-grade squamous intraepithelial lesions (HSILs) in people with HIV (PWH).
RECENT FINDINGS
This review covers relevant studies on the links between the microbiome and HPV infection, cervical dysplasia/cancer, and anal HPV disease. It focuses on anal samples and precancerous lesions.
SUMMARY
The review highlights the promising potential of the anal microbiome as a novel biomarker for precancerous lesions in people with HIV, while also discussing limitations and future research needs.
目的综述
在某些高危人群中，早期发现和治疗人乳头瘤病毒（HPV）相关的肛门发育不良有助于预防肛门癌，但需要新的工具来改善诊断和风险评估。在这里，我们旨在讨论微生物组作为 HIV 感染者（PWH）肛门高级别鳞状上皮内病变（HSIL）潜在生物标志物的作用的证据。
最近的发现
本综述涵盖了有关微生物组与 HPV 感染、宫颈发育不良/癌症和肛门 HPV 疾病之间联系的相关研究。它侧重于肛门样本和癌前病变。
总结
该综述强调了肛门微生物组作为 HIV 感染者癌前病变的新型生物标志物的有前途的潜力，同时也讨论了其局限性和未来的研究需求。
Zotero 插件