代谢综合征加速胰腺导管内乳头状黏液性肿瘤的年龄相关性增长。

Metabolic Syndrome Accelerates the Age-Related Increase of Intraductal Papillary Mucinous Neoplasm of the Pancreas.

机构信息

From the Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo.

Department of Gastroenterology, Yodogawa Christian Hospital, Osaka, Japan.

出版信息

Pancreas. 2024 Jan 1;53(1):e9-e15. doi: 10.1097/MPA.0000000000002267. Epub 2023 Oct 28.

DOI:10.1097/MPA.0000000000002267

PMID:37890158

Abstract

OBJECTIVES

Aging is associated with a high prevalence of pancreatic cysts and intraductal papillary mucinous neoplasms (IPMNs). Metabolic syndrome (MS) may increase the risk of neoplasms, including those that develop in the pancreas. However, the influence of factors associated with MS on the development of IPMN remains unclear.

METHODS

A total of 9363 patients who underwent abdominal ultrasound examinations between April 2012 and May 2013 were included in this study. Multivariate logistic regression analysis was performed to identify factors associated with the presence of IPMN by age.

RESULTS

Pancreatic cysts were detected in 198 of 9363 patients, of whom 129 were found to have IPMNs. The presence of IPMN significantly correlated with age (10-year increments; odds ratio, 2.73; 95% CI, 2.28-3.29; P < 0.001). High body mass index, history of smoking, hyperlipidemia, hypertension, and MS were associated with a higher prevalence of IPMN with advancing age. In multivariate analysis, the presence of IPMN was more frequent in elderly patients with MS (odds ratio, 3.14; 95% CI, 3.14-6.72; P = 0.003).

CONCLUSIONS

The present study suggests that the incidence of IPMN increases with age and is accelerated in the presence of MS.

摘要

目的

衰老与胰腺囊肿和胰管内乳头状黏液性肿瘤（IPMN）的高患病率相关。代谢综合征（MS）可能会增加肿瘤的风险，包括在胰腺中发展的肿瘤。然而，与 MS 相关的因素对 IPMN 发展的影响尚不清楚。

方法

本研究共纳入 9363 名于 2012 年 4 月至 2013 年 5 月期间接受腹部超声检查的患者。采用多变量 logistic 回归分析按年龄确定与 IPMN 存在相关的因素。

结果

在 9363 名患者中，有 198 名患者发现胰腺囊肿，其中 129 名患者被诊断为 IPMN。IPMN 的存在与年龄显著相关（每增加 10 岁；比值比，2.73；95%置信区间，2.28-3.29；P<0.001）。高体重指数、吸烟史、高脂血症、高血压和 MS 与年龄增长相关的 IPMN 患病率增加有关。在多变量分析中，MS 老年患者 IPMN 的存在更为频繁（比值比，3.14；95%置信区间，3.14-6.72；P=0.003）。