Samaan N A, Schultz P N, Leavens T A, Leavens M E, Lee Y Y
Am J Obstet Gynecol. 1986 Dec;155(6):1300-5. doi: 10.1016/0002-9378(86)90164-x.
Prolactinoma was diagnosed in 190 women of the same age range, among whom 88 were treated with transsphenoidal microadenectomy and 102 with bromocriptine. The purpose of this study was to compare the two groups according to classification of the adenomas by size and invasiveness, pregnancy rates, prolactin levels after pregnancy, sella turcica changes after pregnancy, and serum prolactin levels and radiologic changes in patients who were operated on but did not become pregnant or did not desire pregnancy. In the group with operation, 91% of patients who had microadenoma and 88% of those with diffuse adenoma conceived, but none who had invasive tumors did so. In the bromocriptine-treated group, among patients with no visible microadenoma or with microadenoma seen radiologically 56% conceived; among those with diffuse adenoma 66% conceived; no patients with invasive adenoma were in this group. In the group with operation, 21% had higher serum prolactin levels and amenorrhea after pregnancy, compared with 19% in the medical treatment group and 19% in the group with operation who did not conceive. Of all patients studied, radiologic changes in the pituitary fossa were seen in only one patient undergoing operation.
190名年龄范围相同的女性被诊断为泌乳素瘤，其中88人接受了经蝶窦微腺瘤切除术，102人接受了溴隐亭治疗。本研究的目的是根据腺瘤的大小和侵袭性分类、妊娠率、妊娠后催乳素水平、妊娠后蝶鞍变化以及接受手术但未怀孕或不想要怀孕的患者的血清催乳素水平和影像学变化，对两组进行比较。在手术组中，微腺瘤患者的受孕率为91%，弥漫性腺瘤患者的受孕率为88%，但侵袭性肿瘤患者无一受孕。在溴隐亭治疗组中，影像学上未见微腺瘤或可见微腺瘤的患者受孕率为56%；弥漫性腺瘤患者受孕率为66%；该组无侵袭性腺瘤患者。在手术组中，21%的患者妊娠后血清催乳素水平升高且闭经，药物治疗组为19%，手术组中未受孕者为19%。在所有研究患者中，仅1例接受手术的患者出现垂体窝影像学改变。
