Department of Medicine, Division of Mycobacterial Disease and Pulmonary Infections, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
Pulmonary Disease and Critical Care Medicine, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA.
Clin Chest Med. 2023 Dec;44(4):757-769. doi: 10.1016/j.ccm.2023.07.003. Epub 2023 Sep 1.
The diagnosis of nontuberculous mycobacterial (NTM) pulmonary disease is based on three criteria: patient's symptoms, radiographic findings, and microbiologic results. The microbiologic criterion is the most complicated because it requires more than one positive sputum acid-fast bacilli culture. Clinicians are challenged to apply the diagnostic criteria in the context of variable patient symptoms, NTM pathogenicity, and host susceptibility. The decision to treat NTM pulmonary disease entails assessment of the risks and benefits of therapy and the patient's wishes and ability to receive treatment.
非结核分枝杆菌(NTM)肺病的诊断基于三个标准:患者症状、影像学发现和微生物学结果。微生物学标准是最复杂的,因为它需要不止一次阳性痰抗酸杆菌培养。临床医生在患者症状、NTM 致病性和宿主易感性各不相同的情况下应用诊断标准面临挑战。决定是否治疗 NTM 肺病需要评估治疗的风险和益处,以及患者的意愿和接受治疗的能力。