Rostás Róbert, Fekete István, Horváth László, Fekete Klára
Division of Radiology and Imaging Science, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, 4032 Debrecen, Hungary.
Department of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond krt 22, 4032 Debrecen, Hungary.
Brain Sci. 2023 Sep 28;13(10):1384. doi: 10.3390/brainsci13101384.
Amyotrophic lateral sclerosis (ALS) is a fatal form of neuromuscular disease. The aim of this study was to assess changes in the blink reflex (BR) parameters as a valid and easy-to-use tool in ALS patients. We assessed the BR test in patients with a definitive diagnosis of ALS, healthy volunteers, and patients with diseases affecting the peripheral nervous system. The BR was studied in 29 patients who met the Awaji criteria. Latencies were compared with our healthy controls ( = 50) and other diseases of the peripheral nervous system ( = 61). The ALS Functional Rating Scale-Revised (ALSFRS-R) was used to evaluate functional status. Significantly prolonged R2i and R2c latencies were found in the ALS group compared with the healthy control group ( < 0.001). The latencies of R1, R2i, R2c were all increased in the bulbar subtype compared to the limb-onset subtype ( < 0.05). According to our results, BR examination might be a promising tool to monitor the course of the disease or serve as a prognostic biomarker in patients with ALS, but it should be assessed in further studies. The abnormalities detected through BR might help perform earlier interventions in ALS patients and might be useful in other diseases affecting the peripheral nervous system.
肌萎缩侧索硬化症（ALS）是一种致命的神经肌肉疾病。本研究的目的是评估眨眼反射（BR）参数的变化，作为ALS患者一种有效且易于使用的工具。我们对确诊为ALS的患者、健康志愿者以及患有影响周围神经系统疾病的患者进行了BR测试。对29例符合阿波岐标准的患者进行了BR研究。将潜伏期与我们的健康对照组（n = 50）和其他周围神经系统疾病患者（n = 61）进行比较。使用肌萎缩侧索硬化功能评定量表修订版（ALSFRS-R）评估功能状态。与健康对照组相比，ALS组的R2i和R2c潜伏期显著延长（P < 0.001）。与肢体起病亚型相比，延髓亚型的R1、R2i、R2c潜伏期均增加（P < 0.05）。根据我们的结果，BR检查可能是监测ALS患者疾病进程或作为预后生物标志物的一种有前景的工具，但应在进一步研究中进行评估。通过BR检测到的异常可能有助于对ALS患者进行早期干预，并且可能对其他影响周围神经系统的疾病有用。
