Piazza Martin G, Varga Gregory, Welch William, Abel Taylor J
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Brain Sci. 2023 Oct 13;13(10):1455. doi: 10.3390/brainsci13101455.
Drug-resistant epilepsy (DRE) has a strongly negative impact on quality of life, as well as the development of pediatric patients. Surgical treatments have evolved over time, including more invasive craniotomies for resection or disconnection. More recently, neuromodulation techniques have been employed as a less invasive option for patients. Responsive neurostimulation (RNS) is the first closed-loop technology that allows for both treatment and device data collection, which allows for an internal assessment of the efficacy of treatment. This novel technology has been approved in adults and has been used off label in pediatrics. This review seeks to describe this technology, its history, and future directions.
耐药性癫痫（DRE）对生活质量以及儿科患者的发育有着严重的负面影响。随着时间的推移，外科治疗方法不断发展，包括用于切除或切断的侵入性更强的开颅手术。最近，神经调节技术已被用作对患者侵入性较小的选择。响应性神经刺激（RNS）是第一种允许进行治疗和设备数据收集的闭环技术，这使得能够对治疗效果进行内部评估。这项新技术已在成人中获得批准，并已在儿科中用于非标签用途。本综述旨在描述这项技术、其历史和未来发展方向。
