Tokunaga K, Fukushima M, Kemnitz J W, Bray G A
Am J Physiol. 1986 Dec;251(6 Pt 2):R1221-7. doi: 10.1152/ajpregu.1986.251.6.R1221.
Lesions in the ventromedial hypothalamus (VMH) uniformly produced obesity, but lesions in the paraventricular nucleus (PVN) produced obesity in only half of the animals. The obesity in the PVN-lesioned animals was related to the extent of PVN damage and was attenuated by concurrent damage to the dorsomedial nucleus. Comparing the PVN-lesioned rats that became obese with the VMH-lesioned rats that showed comparable weight gain, revealed several differences. The nocturnal intake of food in rats eating ad libitum was lower in the VMH-lesioned rats. Glucose concentrations were also lower in the VMH-lesioned rats, whether eating ad libitum or pair fed. Insulin concentrations were higher in the fatter animals fed ad libitum regardless of the location of the lesion. After pair feeding the insulin values were lower in both VMH- and PVN-lesioned rats than in controls. The diurnal excursion of corticosterone was blunted by both hypothalamic lesions in rats fed ad libitum, but after pair feeding there was less distortion of the diurnal rhythm. These data show that the characteristics of obesity produced by PVN lesions differ from those resulting from VMH damage.
腹内侧下丘脑（VMH）损伤均会导致肥胖，但室旁核（PVN）损伤仅在半数动物中引发肥胖。PVN损伤动物的肥胖与PVN损伤程度相关，且会因背内侧核同时受损而减轻。将变得肥胖的PVN损伤大鼠与体重增加相当的VMH损伤大鼠进行比较，发现了一些差异。随意进食的VMH损伤大鼠夜间食物摄入量较低。无论随意进食还是配对喂养，VMH损伤大鼠的葡萄糖浓度也较低。无论损伤部位如何，随意进食的较胖动物胰岛素浓度较高。配对喂养后，VMH和PVN损伤大鼠的胰岛素值均低于对照组。随意进食的大鼠中，两种下丘脑损伤均会使皮质酮的昼夜波动变钝，但配对喂养后，昼夜节律的扭曲较小。这些数据表明，PVN损伤导致的肥胖特征与VMH损伤导致的肥胖特征不同。
