儿童鼻腔一氧化氮：儿科呼吸医学当前研究综述
Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine.
作者信息
Mrkić Kobal Iva, Turkalj Mirjana, Plavec Davor
机构信息
Outpatient Clinic for Sick Children Dr. Sabol, 10000 Zagreb, Croatia.
Faculty of Medicine, JJ Strossmayer University of Osijek, 31000 Osijek, Croatia.
出版信息
Children (Basel). 2023 Oct 9;10(10):1671. doi: 10.3390/children10101671.
Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to investigate the current state of use of nNO measurement in children. A comprehensive search was conducted using the Web of Science and PubMed databases specifically targeting publications in the English language, with the following keywords: nasal NO, children, allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, primary ciliary dyskinesia (PCD), and cystic fibrosis (CF). We describe the use of nNO in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF based on the latest literature. nNO is a noninvasive, clinically applicable test for use in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF. It can be used as a complementary method in the diagnosis of these respiratory diseases and as a monitoring method for the treatment of allergic rhinitis and acute and chronic rhinosinusitis.
鼻一氧化氮（nNO）是一种由鼻黏膜气道细胞中的诱导型和组成型一氧化氮合酶（NOS）合成的气体。与肺一氧化氮一样，它被认为与儿童各种呼吸道疾病中的气道炎症有关。我们综述的目的是调查儿童nNO测量的应用现状。使用科学网和PubMed数据库进行了全面检索，专门针对英文出版物，关键词如下：鼻一氧化氮、儿童、过敏性鼻炎、慢性鼻-鼻窦炎、急性鼻-鼻窦炎、原发性纤毛运动障碍（PCD）和囊性纤维化（CF）。我们根据最新文献描述了nNO在儿童过敏性鼻炎、慢性鼻-鼻窦炎、急性鼻-鼻窦炎、PCD和CF中的应用。nNO是一种用于儿童过敏性鼻炎、慢性鼻-鼻窦炎、急性鼻-鼻窦炎、PCD和CF的非侵入性、临床适用的检测方法。它可作为这些呼吸道疾病诊断的辅助方法，以及过敏性鼻炎和急慢性鼻-鼻窦炎治疗的监测方法。
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