Takagi Yukinori, Katayama Ikuo, Eida Sato, Sasaki Miho, Shimizu Toshimasa, Sato Shuntaro, Hashimoto Kunio, Mori Hiroki, Otsuru Mitsunobu, Umeda Masahiro, Kumai Yoshihiko, Toya Ryo, Kawakami Atsushi, Sumi Misa
Department of Radiology and Biomedical Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
J Clin Med. 2023 Oct 12;12(20):6487. doi: 10.3390/jcm12206487.
This study aimed to retrospectively investigate the prevalence of Sjögren's syndrome (SS) among patients with ranulas, parotid cysts, or parotid calcifications; identify the characteristic magnetic resonance imaging (MRI) or computed tomography (CT) findings of the lesions associated with SS; and compare the SS disease stages among SS patients with the three lesion types. A total of 228 patients with the lesions were classified into SS, possible SS, and non-SS groups. The prevalence of SS among patients with ranulas, parotid cysts, or parotid calcifications was 16%, 24%, and 40%, and the rates of either SS or possible SS were 25%, 41%, and 64%, respectively. SS was associated with (i) ranulas: ≤17 mm; (ii) parotid cysts: bilateral and multiple; and (iii) parotid calcifications: in females, bilateral, multiple, parenchymal, and no coexisting calcifications in other tissues. SS patients with ranulas were significantly younger and had lower submandibular gland stage scores on MRI/CT than those with other lesions. Additionally, in 58% and 15% of SS patients with ranulas and parotid calcifications, respectively, detection of the lesions led to the diagnosis of primary SS. Therefore, recognizing the prevalence of SS among patients with these lesions and the findings associated with SS can help detect undiagnosed SS.
本研究旨在回顾性调查舌下腺囊肿、腮腺囊肿或腮腺钙化患者中干燥综合征（SS）的患病率；确定与SS相关病变的特征性磁共振成像（MRI）或计算机断层扫描（CT）表现；并比较三种病变类型的SS患者的疾病分期。共有228例有这些病变的患者被分为SS组、可能的SS组和非SS组。舌下腺囊肿、腮腺囊肿或腮腺钙化患者中SS的患病率分别为16%、24%和40%，SS或可能的SS的发生率分别为25%、41%和64%。SS与以下因素相关：（i）舌下腺囊肿：≤17mm；（ii）腮腺囊肿：双侧且多发；（iii）腮腺钙化：女性，双侧，多发，实质内，且其他组织无并存钙化。患有舌下腺囊肿的SS患者比患有其他病变的患者明显年轻，且MRI/CT上的下颌下腺分期得分更低。此外，分别有58%和15%的患有舌下腺囊肿和腮腺钙化的SS患者，病变的检测导致了原发性SS的诊断。因此，认识这些病变患者中SS的患病率以及与SS相关的表现有助于发现未被诊断的SS。
