Nadesapillai Sapthami, Mol Femke, Broer Simone L, Stevens Brentjens Linda B P M, Verhoeven Marieke O, Heida Karst Y, Goddijn Mariëtte, van Golde Ron J T, Bos Annelies M E, van der Coelen Sanne, Peek Ronald, Braat Didi D M, van der Velden Janielle A E M, Fleischer Kathrin
Department of Obstetrics and Gynecology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Department of Obstetrics and Gynecology, Amsterdam University Medical Center, Center for Reproductive Medicine, Amsterdam Reproduction & Development Research Institute, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
J Clin Med. 2023 Oct 13;12(20):6502. doi: 10.3390/jcm12206502.
Turner syndrome (TS) is accompanied with premature ovarian insufficiency. Oocyte vitrification is an established method to preserve fertility. However, data on the oocyte yield in women with TS who vitrify their oocytes and the return rate to utilize the oocytes are scarce.
Retrospective multicenter cohort study. Data was collected from medical records of women with TS who started oocyte vitrification between 2010 and 2021.
Thirty-three women were included. The median cumulative number of vitrified oocytes was 20 per woman. Complications occurred in 4% of the cycles. Significant correlations were found between the cumulative number of vitrified oocytes and AMH (r = 0.54 and < 0.01), AFC (r = 0.49 and < 0.01), percentage of 46,XX cells (r = 0.49 and < 0.01), and FSH (r = -0.65 and < 0.01). Spontaneous ( = 8) and IVF ( = 2) pregnancies occurred in 10 women ± three years after vitrification. So far, none of the women have returned to utilize their vitrified oocytes.
Oocyte vitrification is a feasible fertility preservation option for women with TS, particularly in those with 46,XX cell lines or sufficient ovarian reserve. Multiple stimulation cycles are recommended to reach an adequate number of vitrified oocytes for pregnancy. It is too early to draw conclusions about the utilization of vitrified oocytes in women with TS.
特纳综合征（TS）伴有卵巢早衰。卵母细胞玻璃化是一种成熟的生育力保存方法。然而，关于玻璃化卵母细胞的特纳综合征女性的卵母细胞产量以及卵母细胞利用的回收率的数据很少。
回顾性多中心队列研究。从2010年至2021年开始卵母细胞玻璃化的特纳综合征女性的病历中收集数据。
纳入了33名女性。每位女性玻璃化卵母细胞的累积中位数为20个。4%的周期出现并发症。发现玻璃化卵母细胞的累积数量与抗缪勒管激素（AMH）（r = 0.54，P < 0.01）、窦卵泡计数（AFC）（r = 0.49，P < 0.01）、46,XX细胞百分比（r = 0.49，P < 0.01）和促卵泡生成素（FSH）（r = -0.65，P < 0.01）之间存在显著相关性。玻璃化后±3年，10名女性发生了自然妊娠（n = 8）和体外受精（IVF）妊娠（n = 2）。到目前为止，没有女性回来使用她们玻璃化的卵母细胞。
卵母细胞玻璃化是特纳综合征女性可行的生育力保存选择，特别是对于那些具有46,XX细胞系或卵巢储备充足的女性。建议进行多个刺激周期以获得足够数量的用于妊娠的玻璃化卵母细胞。现在就特纳综合征女性玻璃化卵母细胞的利用得出结论还为时过早。
