Abuhasira Ran, Schwartz Lihi, Novack Victor
Clinical Research Center, Soroka University Medical Center, Be'er-Sheva 8410501, Israel.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva 8410501, Israel.
Biomedicines. 2023 Oct 3;11(10):2697. doi: 10.3390/biomedicines11102697.
The proportion of older adults using medical cannabis is rising. Therefore, we aimed to assess the effects of herbal medical cannabis on the functional status of older adults. We conducted a prospective observational study of patients aged 65 years or older that initiated cannabis treatment for different indications, mostly chronic non-cancer pain, during 2018-2020 in a specialized geriatric clinic. The outcomes assessed were activities of daily living (ADL), instrumental activities of daily living (IADL), pain intensity, geriatric depression scale, chronic medication use, and adverse events at six months. A cohort of 119 patients began cannabis treatment: the mean age was 79.3 ± 8.5 and 74 (62.2%) were female. Of the cohort, 43 (36.1%) experienced adverse effects due to cannabis use and 2 (1.7%) required medical attention. The mean ADL scores before and after treatment were 4.4 ± 1.8 and 4.5 ± 1.8, respectively ( = 0.27), and the mean IADL scores before and after treatment were 4.1 ± 2.6 and 4.7 ± 3, respectively ( = 0.02). We concluded that medical cannabis in older adults has a number of serious adverse events, but was not associated with a decrease in functional status, as illustrated by ADL and IADL scores after six months of continuous treatment.
使用医用大麻的老年人比例正在上升。因此，我们旨在评估草药医用大麻对老年人功能状态的影响。我们对2018年至2020年期间在一家专业老年诊所因不同适应症（主要是慢性非癌性疼痛）开始大麻治疗的65岁及以上患者进行了一项前瞻性观察研究。评估的结果包括日常生活活动（ADL）、工具性日常生活活动（IADL）、疼痛强度、老年抑郁量表、慢性药物使用情况以及六个月时的不良事件。一组119名患者开始了大麻治疗：平均年龄为79.3±8.5岁，74名（62.2%）为女性。在该队列中，43名（36.1%）患者因使用大麻出现不良反应，2名（1.7%）需要医疗护理。治疗前后的平均ADL评分分别为4.4±1.8和4.5±1.8（P=0.27），治疗前后的平均IADL评分分别为4.1±2.6和4.7±3（P=0.02）。我们得出结论，老年人使用医用大麻会出现一些严重不良事件，但与功能状态下降无关，连续治疗六个月后的ADL和IADL评分表明了这一点。
