Rabkin Simon W, Wong Chenille N
Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Division of Cardiology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Biomedicines. 2023 Oct 17;11(10):2815. doi: 10.3390/biomedicines11102815.
This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca-ATPase, oxidative-nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation.
本综述将聚焦于利用DNA甲基化机制的表观遗传修饰，其可能参与射血分数保留的心力衰竭（HFpEF）的发病机制。将讨论HFpEF的假定途径，特别是心肌纤维化、心肌炎症、肌浆网钙-ATP酶、氧化-亚硝化应激、线粒体和代谢缺陷以及肥胖。将从DNA甲基化的角度研究HFpEF与衰老和心房颤动的关系。
