Nosal Briana M, Sakaki Junichi R, Mofrad Manije Darooghegi, Macdonald Zachary, Mahoney Kyle J, Thornton Staci N, Patel Dave, Drossman Joseph, Lee Elaine Choung-Hee, Chun Ock K
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.
Biomedicines. 2023 Oct 19;11(10):2834. doi: 10.3390/biomedicines11102834.
Recent cell and animal studies suggest the potential of blackcurrants (BCs; ) as a dietary agent that may reduce the risk of cardiovascular disease (CVD) by improving dyslipidemia, oxidative stress, and inflammation. This study aimed to examine the effects of BC anthocyanin (ACN) extract supplementation on biomarkers of CVD risk in healthy adult women in menopause transition. The effects of BC ACN supplementation on body composition, fasting blood lipids and biomarkers of inflammation and oxidative stress were evaluated using anthropometric measures and blood samples collected from a pilot randomized controlled clinical trial in peri- and early postmenopausal women. Thirty-eight eligible peri- and early postmenopausal women aged 45-60 completed the entire trial, in which they were randomly assigned into one of three treatment groups: placebo (control group), 392 mg/day (low BC group), or 784 mg/day (high BC group) for six months. The significance of differences in outcomes was tested using repeated-measures ANOVA. Overall, following six-month BC consumption, significantly decreased triglyceride (TG) levels were observed between treatment groups ( < 0.05) in a dose-dependent manner. Plasma interleukin-1β (IL-1β) was significantly reduced in a dose and time dependent manner ( < 0.05). Significant decreases in thiobarbituric acid reactive substances (TBARS) levels were also observed between treatment groups ( < 0.05) in a dose-dependent manner. Six-month change in oxidized LDL was inversely correlated with changes in catalase (CAT) and total antioxidant capacity (TAC) ( < 0.05), while C-reactive protein (hs-CRP) change was positively correlated with changes in TG and IL-1β ( < 0.01). Together, these findings suggest that daily BC consumption for six months effectively improved dyslipidemia, inflammation, and lipid peroxidation, thus potentially mitigating the risk of postmenopausal CVD development in study participants. Future studies with larger sample sizes and at-risk populations are warranted to confirm these findings.
近期的细胞和动物研究表明，黑加仑（BCs）作为一种膳食成分，可能通过改善血脂异常、氧化应激和炎症反应来降低心血管疾病（CVD）的风险。本研究旨在探讨补充黑加仑花青素（ACN）提取物对处于绝经过渡期的健康成年女性心血管疾病风险生物标志物的影响。采用人体测量指标和从围绝经期及绝经后早期女性的一项试点随机对照临床试验中采集的血样，评估补充黑加仑ACN对身体成分、空腹血脂以及炎症和氧化应激生物标志物的影响。38名年龄在45 - 60岁的符合条件的围绝经期及绝经后早期女性完成了整个试验，她们被随机分为三个治疗组之一：安慰剂组（对照组）、392毫克/天（低剂量黑加仑组）或784毫克/天（高剂量黑加仑组），为期6个月。使用重复测量方差分析检验结果差异的显著性。总体而言，在食用黑加仑6个月后，各治疗组之间甘油三酯（TG）水平呈剂量依赖性显著降低（P < 0.05）。血浆白细胞介素 - 1β（IL - 1β）以剂量和时间依赖性方式显著降低（P < 0.05）。各治疗组之间硫代巴比妥酸反应性物质（TBARS）水平也呈剂量依赖性显著降低（P < 0.05）。氧化型低密度脂蛋白（ox - LDL）六个月的变化与过氧化氢酶（CAT）和总抗氧化能力（TAC）的变化呈负相关（P < 0.05），而C反应蛋白（hs - CRP）的变化与TG和IL - 1β的变化呈正相关（P < 0.01）。总之，这些发现表明，连续6个月每日食用黑加仑可有效改善血脂异常、炎症和脂质过氧化，从而可能降低研究参与者绝经后心血管疾病发生的风险。有必要开展样本量更大且针对高危人群的未来研究来证实这些发现。
