Department of Internal Medicine, Erol Olçok Training and Research Hospital, 19040 Çorum, Turkey.
Circad Health, 71330 Nora, Sweden.
Medicina (Kaunas). 2023 Oct 9;59(10):1795. doi: 10.3390/medicina59101795.
: Chronic kidney disease (CKD) is a global public health issue with rising incidence linked to substantial morbidity and mortality. Selenium, an antioxidant trace element, has been linked to low serum levels in end-stage renal disease. Restless Leg Syndrome (RLS), a sleep disorder, is prevalent in CKD patients and significantly impacts their quality of life. The objective of this study was to examine the correlation between serum selenium levels and the prevalence of restless leg syndrome in individuals with chronic kidney disease. : Forty-six CKD patients undergoing serum selenium level assessments between 1 January 2020 and 28 February 2022, at the Hitit University Faculty of Medicine Department of Nephrology Outpatient Clinic or Hemodialysis Unit, were included. Patients over 18 years of age with no history of hematological or oncological diseases or acute or chronic inflammatory conditions were included in the study groups. Patients taking selenium supplements were excluded. Demographic data, comorbidities, and laboratory values were collected, and RLS presence and severity were evaluated. Statistical analyses include descriptive statistics, correlation analysis, the Mann-Whitney U test, Student's test, and Chi-square test. : Among the 46 patients, 16 (34.78%) had RLS symptoms. The patient group included 34.78% predialysis, 34.78% peritoneal dialysis, and 30.44% hemodialysis patients, with a median age of 47.98 years. There was no difference in age, gender, and Charlson comorbidity between patients with or without RLS ( = 0.881, = 0.702, = 0.650). RLS prevalence varied across CKD subgroups, with hemodialysis patients having a higher prevalence ( = 0.036). Clinical parameters such as blood urea nitrogen, creatinine, calcium, phosphorus, platelet counts, and parathyroid hormone levels exhibited significant differences between patients with and without RLS ( < 0.05). Serum selenium levels were not significantly different between patients with and without RLS ( = 0.327). : With an increased comorbidity burden, CKD poses a significant healthcare challenge. When accompanied by RLS, this burden can be debilitating. The difference in CKD stages between groups has shed light on a critical determinant of RLS in this population, emphasizing the role of the chronic kidney disease stage. In our study, serum selenium levels were not associated with the presence and severity of RLS. However, prospective studies with larger numbers of participants are needed to draw a definitive conclusion.
慢性肾脏病（CKD）是一个全球性的公共卫生问题，其发病率不断上升，与大量发病率和死亡率相关。硒是一种抗氧化微量元素，与终末期肾病患者的血清水平低有关。不宁腿综合征（RLS）是一种睡眠障碍，在 CKD 患者中很常见，严重影响他们的生活质量。本研究的目的是探讨慢性肾脏病患者血清硒水平与不宁腿综合征患病率之间的相关性。
2020 年 1 月 1 日至 2022 年 2 月 28 日，在哈提特大学医学院肾病门诊或血液透析科进行血清硒水平评估的 46 例 CKD 患者被纳入研究。纳入无血液系统或肿瘤疾病或急性或慢性炎症性疾病史的年龄在 18 岁以上的患者。排除服用硒补充剂的患者。收集了人口统计学数据、合并症和实验室值，并评估了 RLS 的存在和严重程度。统计分析包括描述性统计、相关性分析、Mann-Whitney U 检验、学生 t 检验和卡方检验。
在 46 名患者中，有 16 名（34.78%）有 RLS 症状。患者组包括 34.78%的透析前患者、34.78%的腹膜透析患者和 30.44%的血液透析患者，中位年龄为 47.98 岁。有无 RLS 的患者在年龄、性别和 Charlson 合并症方面无差异（ = 0.881， = 0.702， = 0.650）。RLS 的患病率在 CKD 亚组中有所不同，血液透析患者患病率较高（ = 0.036）。有或没有 RLS 的患者之间的临床参数如血尿素氮、肌酐、钙、磷、血小板计数和甲状旁腺激素水平有显著差异（ < 0.05）。有或没有 RLS 的患者之间的血清硒水平没有显著差异（ = 0.327）。
随着合并症负担的增加，CKD 对医疗保健构成了重大挑战。当伴有 RLS 时，这种负担可能会使人衰弱。各组之间的 CKD 阶段差异揭示了 RLS 在该人群中的一个关键决定因素，强调了慢性肾脏病阶段的作用。在我们的研究中，血清硒水平与 RLS 的存在和严重程度无关。然而，需要更多参与者的前瞻性研究来得出明确的结论。
