Eye Clinic, Military Medical Academy, 11000 Belgrade, Serbia.
Faculty of Medicine of the Military Medical Academy, University of Defense, 11000 Belgrade, Serbia.
Medicina (Kaunas). 2023 Oct 14;59(10):1829. doi: 10.3390/medicina59101829.
: Early diagnosis of the exudative form of age-related macular degeneration (AMD) is very important for a timely first treatment, which is directly related to the preservation of functional visual acuity over a long period. The goal of this paper was to examine the correlation between the double-layer sign (DLS) and the presence of non-exudative macular neovascularization (MNV). : Our research included 60 patients with AMD, exudative in one eye and non-exudative in the other eye. We analyzed only the non-exudative form using optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A). The patients were classified into three groups, depending on the duration of the disease (<2 years, 2 to 5 years, >5 years). The onset of the disease was deemed the moment of establishing a diagnosis of exudative AMD in one eye. We defined the presence or absence of a DLS using OCT and the presence of non-exudative MNV using OCT-A, both on 3 × 3 mm and 6 × 6 mm sections. DLS was used as a projection biomarker for non-exudative MNV, with the aim of establishing a rapid diagnosis and achieving early treatment of the disease. : We found that there was a statistically significant correlation between the DLS diagnosed using OCT and non-exudative MNV diagnosed by OCT-A for both 3 × 3 mm ( < 0.001) and 6 × 6 mm ( < 0.001) imaging. There was a statistically significant difference between the frequencies of both DLS and MNV in Groups I and III on both 3 × 3 and 6 × 6 mm imaging. A statistically significant difference was also noted in the frequencies of DLS and MNV on 6 × 6 mm imaging, but not on 3 × 3 mm imaging, between Groups I and II. No differences were found between the frequencies of DLS and MNV between Groups II and III. : The DLS on OCT can be used as a projection biomarker to assess the presence of a non-exudative MNV.
: 早期诊断年龄相关性黄斑变性（AMD）的渗出型对于及时进行首次治疗非常重要，因为这直接关系到长期内保持功能性视力。本文旨在研究双层征（DLS）与非渗出性黄斑新生血管（MNV）的相关性。: 我们的研究纳入了 60 例 AMD 患者，一只眼为渗出型，另一只眼为非渗出型。我们仅使用光学相干断层扫描（OCT）和光学相干断层扫描血管造影（OCT-A）对非渗出型进行分析。根据疾病持续时间（<2 年、2-5 年、>5 年）将患者分为三组。疾病的发病时间被定义为一只眼确诊为渗出型 AMD 的时间。我们使用 OCT 定义 DLS 的存在与否，使用 OCT-A 定义非渗出性 MNV 的存在与否，在 3×3mm 和 6×6mm 两个部位进行。DLS 作为非渗出性 MNV 的投影生物标志物，旨在快速诊断疾病并实现早期治疗。: 我们发现，OCT 诊断的 DLS 与 OCT-A 诊断的非渗出性 MNV 在 3×3mm（<0.001）和 6×6mm（<0.001）图像上均存在显著的相关性。在 3×3mm 和 6×6mm 图像上，I 组和 III 组的 DLS 和 MNV 的发生率均存在显著差异。在 6×6mm 图像上，I 组和 II 组的 DLS 和 MNV 的发生率也存在显著差异，但在 3×3mm 图像上没有差异。在 II 组和 III 组之间，DLS 和 MNV 的发生率没有差异。: OCT 上的 DLS 可以作为评估非渗出性 MNV 存在的投影生物标志物。
