Zhang Xueqi, Tian Lijun, Teng Di, Teng Weiping
Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
Cancers (Basel). 2023 Oct 17;15(20):5017. doi: 10.3390/cancers15205017.
Thyroid Stimulating Hormone (TSH) is a hormone secreted by the pituitary gland and plays a role in regulating the production and secretion of thyroid hormones by the thyroid gland. This precise feedback loop is essential for maintaining a harmonious balance of thyroid hormones in the body, which are vital for numerous physiological processes. Consequently, TSH serves as a significant marker in assessing thyroid function, and deviations from normal TSH levels may indicate the presence of a thyroid disorder. Thyroid cancer (TC) is the malignant tumor within the endocrine system. In recent years, numerous experts have dedicated their efforts to discovering efficacious biomarkers for TC. These biomarkers aim to improve the accurate identification of tumors with a poor prognosis, as well as facilitate active monitoring of tumors with a more favorable prognosis. The role of TSH in the thyroid gland underscores its potential influence on the occurrence and progression of TC, which has garnered attention in the scientific community. However, due to the limited scope of clinical research and the dearth of high-quality foundational studies, the precise impact of TSH on TC remains unclear. Consequently, we present a comprehensive review of this subject, aiming to offer a valuable reference for future research endeavors.
促甲状腺激素（TSH）是一种由垂体分泌的激素，在调节甲状腺产生和分泌甲状腺激素方面发挥作用。这种精确的反馈回路对于维持体内甲状腺激素的和谐平衡至关重要，而甲状腺激素对众多生理过程至关重要。因此，TSH是评估甲状腺功能的重要指标，TSH水平偏离正常范围可能表明存在甲状腺疾病。甲状腺癌（TC）是内分泌系统中的恶性肿瘤。近年来，众多专家致力于发现TC的有效生物标志物。这些生物标志物旨在提高对预后不良肿瘤的准确识别，并促进对预后较好肿瘤的积极监测。TSH在甲状腺中的作用凸显了其对TC发生和进展的潜在影响，这已引起科学界的关注。然而，由于临床研究范围有限且高质量基础研究匮乏，TSH对TC的确切影响仍不明确。因此，我们对该主题进行全面综述，旨在为未来的研究工作提供有价值的参考。
