Department of Psychiatry, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Int J Mol Sci. 2023 Oct 11;24(20):15092. doi: 10.3390/ijms242015092.
Recent studies have demonstrated the pivotal role of locus coeruleus (LC) and salience network (SN) resting state functional connectivity (rsFC) changes in the early stage of Alzheimer's disease (AD). Moreover, sex has been a crucial point of discussion in understanding AD pathology. We aimed to demonstrate the sex-related disparities in the functional connectivity (FC) of the SN and LC in preclinical AD. A total of 89 cognitively normal patients with evidence of amyloid beta (Aβ) accumulation ([18F] flutemetamol +) were recruited in the study. A seed-to-voxel analysis was conducted to measure the LC and SN rsFC differences between sexes. In addition, sex by Aβ interactive effects on FC values were analyzed with a general linear model. There were statistically significant sex by regional standardized uptake value ratio (SUVR) interactions in the LC FC with the parietal, frontal, and occipital cortices. Moreover, there was a significant sex by global SUVR interaction in the SN FC with the temporal cortex. The findings suggest that there are differential patterns of LC FC and SN FC in males and females with preclinical AD, which interact with regional Aβ deposition.
最近的研究表明，蓝斑（LC）和突显网络（SN）静息态功能连接（rsFC）变化在阿尔茨海默病（AD）的早期阶段起着关键作用。此外，性别是理解 AD 病理的一个重要讨论点。我们旨在展示在临床前 AD 中 SN 和 LC 的功能连接（FC）的性别差异。在这项研究中，共招募了 89 名认知正常的患者，这些患者有淀粉样蛋白 β（Aβ）积累的证据（[18F] flutemetamol +）。采用种子到体素分析来测量 LC 和 SN 的 rsFC 差异。此外，还使用一般线性模型分析了 FC 值的性别与 Aβ 相互作用。LC 与顶叶、额叶和枕叶的 FC 存在统计学显著的性别与区域标准化摄取值比（SUVR）的相互作用。此外，SN 与颞叶的 FC 存在显著的性别与全局 SUVR 相互作用。研究结果表明，在有临床前 AD 的男性和女性中，LC FC 和 SN FC 的模式存在差异，与局部 Aβ 沉积有关。
