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揭示局部吸入性类固醇治疗喉部肉芽肿的作用:一项系统评价

Unraveling the Power of Topical Inhaled Steroids in Treating Laryngeal Granulomas: A Systematic Review.

作者信息

Alarfaj Abdullah A

机构信息

Otolaryngology Unit, Department of Surgery, King Faisal University, Al Ahsa 31982, Saudi Arabia.

出版信息

Life (Basel). 2023 Sep 29;13(10):1984. doi: 10.3390/life13101984.

Abstract

The efficacy of inhaled steroids in the treatment of airway laryngeal granuloma is an important topic of research, given the increasing prevalence of this condition. In this systematic review, we aimed to evaluate the existing evidence on the effectiveness of inhaled steroids in treating airway granuloma. The search was performed in several electronic databases including PubMed, Embase, and the Cochrane Library. We included all relevant studies that were published in the English language between 2005 and 2021. A total of nine studies were eligible for inclusion in our systematic review, including one randomized controlled trial, one case-control study, and seven retrospective studies. The results of our review suggest that inhaled steroids may be effective in treating airway granuloma, but more research is needed to confirm these findings. The limitations of the included studies, such as small sample sizes, inconsistent study designs, and a lack of long-term follow-up, suggest that additional research is needed to confirm the effectiveness of inhaled steroids in treating airway granuloma. Overall, this systematic review highlights the need for further studies to confirm the effectiveness of inhaled steroids in treating airway granuloma.

摘要

鉴于气道喉肉芽肿的患病率不断上升,吸入性类固醇治疗气道喉肉芽肿的疗效是一个重要的研究课题。在这项系统评价中,我们旨在评估吸入性类固醇治疗气道肉芽肿有效性的现有证据。检索在多个电子数据库中进行,包括PubMed、Embase和Cochrane图书馆。我们纳入了2005年至2021年间发表的所有相关英文研究。共有9项研究符合纳入我们系统评价的条件,包括1项随机对照试验、1项病例对照研究和7项回顾性研究。我们的评价结果表明,吸入性类固醇可能对治疗气道肉芽肿有效,但需要更多研究来证实这些发现。纳入研究的局限性,如样本量小、研究设计不一致以及缺乏长期随访,表明需要更多研究来证实吸入性类固醇治疗气道肉芽肿的有效性。总体而言,这项系统评价强调了进一步研究以证实吸入性类固醇治疗气道肉芽肿有效性的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c4/10608710/741a4b5c2f9e/life-13-01984-g001.jpg

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