Department of Tumor Cell Biology, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 1088639, Japan.
Aiseikai-Memorial Ibaraki Welfare and Medical Center, Ibaraki 3100836, Japan.
Viruses. 2023 Sep 26;15(10):2002. doi: 10.3390/v15102002.
The main mode of mother-to-child transmission of the human T-cell leukemia virus (HTLV)-1 is through breastfeeding. Although the most reliable nutritional regimen to prevent HTLV-1 transmission is exclusive formula feeding, a recent meta-analysis revealed that short-term breastfeeding within 90 days does not increase the risk of infection. The protocol of the Japanese Health, Labor, and Welfare Science Research Group primarily recommended exclusive formula feeding for mothers who are positive for HTLV-1. However, there has been no quantitative research on the difficulties experienced by HTLV-1-positive mothers in carrying out these nutritional regimens, including the psychological burden. Therefore, this review was performed to clarify the burdens and difficulties encountered by mothers who are positive for HTLV-1; to this end, we analyzed the data registrants on the HTLV-1 career registration website "Carri-net" website. The data strongly suggest that it is not sufficient to simply recommend exclusive formula feeding or short-term breastfeeding as a means of preventing mother-to-child transmission; it is important for health care providers to understand that these nutritional regimens represent a major burden for pregnant women who are positive for HTLV-1 and to provide close support to ensure these women's health.
人类 T 细胞白血病病毒 (HTLV)-1 的主要母婴传播模式是通过母乳喂养。虽然预防 HTLV-1 传播最可靠的营养方案是完全配方喂养，但最近的一项荟萃分析显示，在 90 天内短期母乳喂养不会增加感染风险。日本卫生、劳动和福利科学研究组的方案主要建议 HTLV-1 阳性的母亲进行完全配方喂养。然而，对于 HTLV-1 阳性母亲在实施这些营养方案（包括心理负担）方面所经历的困难，尚未进行定量研究。因此，进行了这项综述，以阐明 HTLV-1 阳性母亲所面临的负担和困难；为此，我们分析了 HTLV-1 职业登记网站“Carri-net”上的数据登记者。数据强烈表明，简单地推荐完全配方喂养或短期母乳喂养作为预防母婴传播的手段是不够的；卫生保健提供者必须了解，这些营养方案对 HTLV-1 阳性孕妇来说是一个重大负担，并提供密切支持，以确保这些妇女的健康。
