二甲基亚砜增强酮康唑对小鼠血脑屏障的穿透能力。
Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide.
作者信息
Iwen P C, Miller N G
出版信息
Antimicrob Agents Chemother. 1986 Oct;30(4):617-8. doi: 10.1128/AAC.30.4.617.
Abstract
Mice were treated with ketoconazole with and without dimethyl sulfoxide. Concentrations of ketoconazole at 3 and 5 h after treatment were significantly higher in serum (P less than 0.05) and brain tissue homogenate (P less than 0.01) of mice treated with dimethyl sulfoxide than in those of mice not treated with dimethyl sulfoxide.
摘要
对小鼠分别给予酮康唑治疗，其中部分小鼠同时给予二甲基亚砜。治疗后3小时和5小时，给予二甲基亚砜的小鼠血清（P<0.05）和脑组织匀浆（P<0.01）中酮康唑的浓度显著高于未给予二甲基亚砜的小鼠。
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