二甲基亚砜增强酮康唑对小鼠血脑屏障的穿透能力。
Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide.
作者信息
Iwen P C, Miller N G
出版信息
Antimicrob Agents Chemother. 1986 Oct;30(4):617-8. doi: 10.1128/AAC.30.4.617.
Abstract
Mice were treated with ketoconazole with and without dimethyl sulfoxide. Concentrations of ketoconazole at 3 and 5 h after treatment were significantly higher in serum (P less than 0.05) and brain tissue homogenate (P less than 0.01) of mice treated with dimethyl sulfoxide than in those of mice not treated with dimethyl sulfoxide.
摘要
对小鼠分别给予酮康唑治疗，其中部分小鼠同时给予二甲基亚砜。治疗后3小时和5小时，给予二甲基亚砜的小鼠血清（P<0.05）和脑组织匀浆（P<0.01）中酮康唑的浓度显著高于未给予二甲基亚砜的小鼠。
相似文献
1
Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide.二甲基亚砜增强酮康唑对小鼠血脑屏障的穿透能力。
Antimicrob Agents Chemother. 1986 Oct;30(4):617-8. doi: 10.1128/AAC.30.4.617.
2
The use of dimethyl sulfoxide to reversibly open the blood-brain barrier to protein.使用二甲基亚砜可逆地打开血脑屏障以允许蛋白质通过。
Neurosurgery. 1983 Feb;12(2):251. doi: 10.1097/00006123-198302000-00024.
3
Morphologic effect of dimethyl sulfoxide on the blood-brain barrier.二甲基亚砜对血脑屏障的形态学影响。
Science. 1982 Jul 9;217(4555):164-6. doi: 10.1126/science.7089551.
4
Pemoline levels in brain: enhancement by dimethyl sulfoxide.
Science. 1967 Dec 15;158(3807):1479-80. doi: 10.1126/science.158.3807.1479.
5
Little effect of dimethyl sulfoxide on blood-brain barrier to dopamine.
Experientia. 1984 Aug 15;40(8):859-61. doi: 10.1007/BF01951995.
6
Dimethyl sulfoxide: breakdown of blood-brain barrier?二甲基亚砜：血脑屏障的破坏？
Science. 1968 Jun 28;160(3835):1472-3. doi: 10.1126/science.160.3835.1472.
7
Dimethyl sulfoxide: breakdown of blood-brain barrier?二甲基亚砜：血脑屏障的破坏？
Science. 1968 Jun 28;160(3835):1473. doi: 10.1126/science.160.3835.1473.
8
Ineffectiveness of dimethyl sulfoxide in altering the permeability of the blood-brain barrier.二甲基亚砜改变血脑屏障通透性的无效性。
Cryobiology. 1977 Oct;14(5):592-7. doi: 10.1016/0011-2240(77)90169-9.
9
Effect of dimethyl sulfoxide on blood-to-brain transfer of alpha-aminoisobutyric acid: examination of regional blood-brain barrier function.
Neurosci Lett. 1988 Jun 17;89(1):74-9. doi: 10.1016/0304-3940(88)90483-1.
10
Increase of blood-brain barrier permeability to catecholamines by dimethyl sulphoxide in the neonate chick.新生雏鸡中二甲亚砜对血脑屏障儿茶酚胺通透性的影响
J Pharm Pharmacol. 1971 May;23(5):386-7. doi: 10.1111/j.2042-7158.1971.tb09936.x.
引用本文的文献
1
Drugs used for the treatment of cerebral and disseminated infections caused by free-living amoebae.用于治疗由自由生活的阿米巴引起的脑和播散性感染的药物。
Clin Transl Sci. 2021 May;14(3):791-805. doi: 10.1111/cts.12955. Epub 2021 Mar 1.
2
Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells.酮康唑和泊沙康唑选择性靶向表达 HK2 的脑胶质瘤细胞。
Clin Cancer Res. 2019 Jan 15;25(2):844-855. doi: 10.1158/1078-0432.CCR-18-1854. Epub 2018 Oct 15.
本文引用的文献
1
The effect of dimethyl sulfoxide on tissue distribution of gentamicin.
Experientia. 1980 Jan 15;36(1):92-3. doi: 10.1007/BF02003993.
2
Morphologic effect of dimethyl sulfoxide on the blood-brain barrier.二甲基亚砜对血脑屏障的形态学影响。
Science. 1982 Jul 9;217(4555):164-6. doi: 10.1126/science.7089551.
3
Expanding the definition of the blood-brain barrier to protein.将血脑屏障的定义扩展至蛋白质。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7820-4. doi: 10.1073/pnas.78.12.7820.
4
Blood-brain barrier disruption in immature Fischer 344 rats.未成熟费希尔344大鼠的血脑屏障破坏
J Neurosurg. 1984 Apr;60(4):743-50. doi: 10.3171/jns.1984.60.4.0743.
5
Treatment of murine pulmonary cryptococcosis with ketoconazole and amphotericin B.
J Infect Dis. 1984 Apr;149(4):650. doi: 10.1093/infdis/149.4.650.
6
High-dose ketoconazole for treatment of fungal infections of the central nervous system.高剂量酮康唑用于治疗中枢神经系统真菌感染。
Ann Intern Med. 1983 Feb;98(2):160-7. doi: 10.7326/0003-4819-98-2-160.
7
Ketoconazole therapy of murine cryptococcal meningitis.
Am Rev Respir Dis. 1982 Jun;125(6):696-700. doi: 10.1164/arrd.1982.125.6.696.
8
Disposition of ketoconazole, an oral antifungal, in humans.酮康唑（一种口服抗真菌药）在人体内的处置。
Antimicrob Agents Chemother. 1982 Jan;21(1):151-8. doi: 10.1128/AAC.21.1.151.
9
Sensitive bioassay for ketoconazole in serum and cerebrospinal fluid.血清和脑脊液中酮康唑的灵敏生物测定法。
Antimicrob Agents Chemother. 1981 Jul;20(1):59-62. doi: 10.1128/AAC.20.1.59.
10
Inability of dimethyl sulfoxide and 5-fluorouracil to open the blood-brain barrier.
Neurosurgery. 1983 Jan;12(1):29-34. doi: 10.1227/00006123-198301000-00006.
Zotero 插件