Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Nutr Cancer. 2024;76(1):1-16. doi: 10.1080/01635581.2023.2274135. Epub 2023 Dec 27.
Until now, no study evaluated the impact of optimum intake of omega-3 fatty acids on inflammatory factors. We aimed to investigate the dose-dependent effects of omega-3 fatty acids supplementation on inflammatory factors in cancer patients. PubMed, Scopus and ISI Web of Science were searched until July 2022 to find randomized controlled trials (RCTs) for examining the efficacy of omega-3 fatty acids on inflammatory factors. Our primary outcomes were interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and albumin. The results of 33 trials (2068 participants) revealed that each 1 g/day omega-3 fatty acids (oral/enteral) significantly reduced IL-6 (SMD: -1.17 pg/ml; 95% CI: -1.78, -0.55; < 0.001; GRADE = moderate), and TNF-α (SMD: -2.15 pg/ml; 95% CI: -3.14, -1.16; < 0.001; GRADE = very low). Moreover, each 0.5 g/kg/day omega-3 fatty acids (parenteral) significantly reduced TNF-α (SMD: -1.11 pg/ml; 95% CI: -2.02, -0.19; = 0.017; GRADE = low). With moderate and very low evidence certainty, each 1 g/day of omega-3 fatty acids supplementation (oral/enteral) has a beneficial effect on IL-6 and TNF-α. Each 0.5 g/kg/day omega-3 fatty acids (parenteral) could also exert a favorable impact on TNF-α, but the certainty of the evidence was low.
到目前为止，尚无研究评估ω-3 脂肪酸最佳摄入量对炎症因子的影响。我们旨在研究 ω-3 脂肪酸补充剂对癌症患者炎症因子的剂量依赖性影响。我们检索了 PubMed、Scopus 和 ISI Web of Science，以查找截至 2022 年 7 月评估 ω-3 脂肪酸对炎症因子疗效的随机对照试验（RCT）。我们的主要结局指标是白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C 反应蛋白（CRP）和白蛋白。33 项试验（2068 名参与者）的结果表明，每天 1 g ω-3 脂肪酸（口服/肠内）可显著降低 IL-6（SMD：-1.17 pg/ml；95%CI：-1.78，-0.55； < 0.001；GRADE：中等）和 TNF-α（SMD：-2.15 pg/ml；95%CI：-3.14，-1.16； < 0.001；GRADE：极低）。此外，每天 0.5 g/kg ω-3 脂肪酸（静脉内）可显著降低 TNF-α（SMD：-1.11 pg/ml；95%CI：-2.02，-0.19； = 0.017；GRADE：低）。基于中等和极低证据确定性，每天 1 g ω-3 脂肪酸补充剂（口服/肠内）对 IL-6 和 TNF-α具有有益作用。每天 0.5 g/kg ω-3 脂肪酸（静脉内）也可能对 TNF-α产生有利影响，但证据确定性较低。
