Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
J Hum Nutr Diet. 2024 Feb;37(1):354-364. doi: 10.1111/jhn.13261. Epub 2023 Nov 28.
To explore the association between the diet inflammatory index (DII) and infertility.
Multivariable logistic regression was performed to investigate the relationship between infertility and DII, and restricted cubic spline (RCS) was utilised to test for nonlinear relationships in this cross-sectional study. Data of this study were collected from the 2013 to 2020 National Health and Nutrition Examination Survey (NHANES) database. Considering women's child-bearing age, we enrolled a total of 2066 women aged 20-45 years in this study.
After all covariates were adjusted, a positive association was found between DII score and odds of infertility by multivariable logistic regression (odds ratio [OR] = 1.19, 95% confidence interval [CI] 1.03, 1.38; p = 0.027). Compared with participants with DII scores in the lowest quartile, those with DII scores in the highest quartile had significantly higher odds of infertility (OR = 2.42, 95% CI 1.09, 5.34; p = 0.034). The RCSs model suggested a linear relationship between DII and infertility (p for nonlinear = 0.1827).
A positive association between a pro-inflammatory diet and self-reported infertility was detected. Our study extends the application of the DII scoring system to infertility prevention.
探讨饮食炎症指数（DII）与不孕之间的关联。
采用多变量逻辑回归分析方法，研究不孕与 DII 之间的关系，并采用限制性立方样条（RCS）检验此横断面研究中的非线性关系。本研究的数据来自 2013 年至 2020 年全国健康与营养调查（NHANES）数据库。考虑到女性的生育年龄，我们共纳入了 2066 名 20-45 岁的女性。
在调整了所有协变量后，多变量逻辑回归分析发现 DII 评分与不孕的比值比（OR）呈正相关（OR=1.19，95%置信区间[CI]为 1.03-1.38；p=0.027）。与 DII 评分处于最低四分位数的参与者相比，DII 评分处于最高四分位数的参与者不孕的比值比明显更高（OR=2.42，95%CI 为 1.09-5.34；p=0.034）。RCS 模型表明 DII 与不孕之间存在线性关系（p 非线性=0.1827）。
发现促炎饮食与自我报告的不孕之间存在正相关。本研究将 DII 评分系统的应用扩展到不孕预防领域。
