Wei Dongfan, Xu Wen, Song Xiuzu
Department of Dermatology, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, West Lake Road 38, Hangzhou, 310009, People's Republic of China.
Department of Dermatology, Affiliated Hangzhou Dermatology Hospital, Hangzhou Third People's Hospital, Zhejiang University School of Medicine, West Lake Road 38, Hangzhou, 310009, People's Republic of China.
Eur J Nutr. 2025 Apr 19;64(4):160. doi: 10.1007/s00394-025-03677-y.
The potential role of diet-related inflammatory responses in skin carcinogenesis is gaining increasing recognition. This study investigated the association between the Dietary Inflammatory Index (DII) and different types of skin cancer in the United States general population.
The study analyzed cross-sectional data on 45,409 participants in the 1999-2018 National Health and Nutrition Examination Survey (NHANES). The association between the DII and different types of skin cancer was estimated using weighted multivariable logistic regression, and its non-linearity was examined using restricted cubic spline (RCS) regression. Subgroup analyses were stratified by age, sex, race, body mass index, hypertension status, diabetes status, and frequency of skin-protecting behaviors.
The adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for melanoma were 1.54 (1.02-2.35), 1.67 (1.02-2.73), and 1.55 (0.86-2.80) for the second, third, and fourth DII quartiles, respectively, compared with the first quartile. The adjusted ORs with 95% CIs for non-melanoma skin cancer (NMSC) were 0.90 (0.68-1.19), 0.96 (0.69-1.35), and 1.01 (0.70-1.45) for the second, third, and fourth DII quartiles, respectively, compared with the first quartile. The RCS curves showed no overall or non-linear significant association between DII and melanoma prevalence (P = 0.240, Pnon-linearity = 0.144) or NMSC (P = 0.068, Pnon-linearity = 0.410).
This study suggests that Compared with participants in DII quartile 1, those in DII quartiles 2 and 3 had a significantly increased risk of melanoma, whereas those in quartile 4 did not. These findings underscore the potential role of dietary inflammation in melanoma etiology and highlight the importance of further research to better understand and mitigate this risk factor.
饮食相关的炎症反应在皮肤癌发生中的潜在作用日益受到认可。本研究调查了美国普通人群中饮食炎症指数（DII）与不同类型皮肤癌之间的关联。
该研究分析了1999 - 2018年国家健康与营养检查调查（NHANES）中45409名参与者的横断面数据。使用加权多变量逻辑回归估计DII与不同类型皮肤癌之间的关联，并使用受限立方样条（RCS）回归检查其非线性。亚组分析按年龄、性别、种族、体重指数、高血压状态、糖尿病状态和皮肤保护行为频率分层。
与第一四分位数相比，第二、第三和第四DII四分位数的黑色素瘤调整优势比（OR）及95%置信区间（CI）分别为1.54（1.02 - 2.35）、1.67（1.02 - 2.73）和1.55（0.86 - 2.80）。与第一四分位数相比，第二、第三和第四DII四分位数的非黑色素瘤皮肤癌（NMSC）调整OR及95%CI分别为0.90（0.68 - 1.19）、0.96（0.69 - 1.35）和1.01（0.70 - 1.45）。RCS曲线显示DII与黑色素瘤患病率（P = 0.240，非线性P = 0.144）或NMSC（P = 0.068，非线性P = 0.410）之间无总体或非线性显著关联。
本研究表明，与DII四分位数1的参与者相比，DII四分位数2和3的参与者患黑色素瘤的风险显著增加，而四分位数4的参与者则没有。这些发现强调了饮食炎症在黑色素瘤病因中的潜在作用，并突出了进一步研究以更好地理解和减轻这一风险因素的重要性。
