Department of Clinical Biochemistry, Aalborg University Hospital.
Department of Clinical Medicine, Aalborg University.
Dan Med J. 2023 Oct 24;70(11):A05230318.
The diagnosis and management of subacute thyroiditis (SAT) may be challenging, and more evidence on patient and disease characteristics is warranted.
This was a retrospective cohort study of all patients in the North Denmark Region with a SAT diagnosis in the Danish National Patient Registry, 2016-2018. The medical records and biochemical results prior to the diagnosis and during a two-year follow-up period were reviewed.
A total of 71 patients with a SAT diagnosis were identified, and the diagnosis was verified in 44 (62.0%) cases with an incidence rate of 2.4/100,000/year. Patients with verified SAT were predominantly females (72.7%) with a median age of 50.7 years. Biochemical results showed thyrotoxicosis at the initial examination in 69.8% and elevated C-reactive protein in 86.5% of patients. Longitudinal biochemical assessment showed a biphasic response (median thyroid-stimulating hormone, initially: 0.02 mIU/l, at three months: 4.7 mIU/l and 2.4 mIU/l after two years). Treatment with non-steroidal anti-inflammatory drugs, beta-blockers and/or prednisolone was initiated in 23 of the 38 patients (60.5%) evaluated, and ten of 33 patients (30.3%) with follow-up data received thyroid hormone replacement therapy.
In the North Denmark Region, a hospital diagnosis of SAT was verified in less than two thirds of cases. Further large studies are warranted to extend the findings concerning the treatment and outcome of SAT.
None.
Not relevant.
亚急性甲状腺炎（SAT）的诊断和管理可能具有挑战性，需要更多关于患者和疾病特征的证据。
这是一项回顾性队列研究，纳入了 2016 年至 2018 年期间丹麦全国患者注册中心中所有被诊断为 SAT 的北丹麦地区患者。对诊断前和两年随访期间的病历和生化结果进行了回顾。
共确定了 71 例 SAT 诊断患者，其中 44 例（62.0%）经证实，发病率为 2.4/100,000/年。经证实的 SAT 患者主要为女性（72.7%），中位年龄为 50.7 岁。生化结果显示，69.8%的患者初诊时表现为甲状腺毒症，86.5%的患者 C 反应蛋白升高。纵向生化评估显示出双相反应（中位数促甲状腺激素，初诊时：0.02 mIU/l，三个月时：4.7 mIU/l，两年后为 2.4 mIU/l）。对 38 例评估患者中的 23 例（60.5%）启动了非甾体抗炎药、β 受体阻滞剂和/或泼尼松龙治疗，33 例有随访数据的患者中有 10 例（30.3%）接受了甲状腺激素替代治疗。
在北丹麦地区，不到三分之二的 SAT 病例被医院确诊。需要进一步开展大型研究，以扩展关于 SAT 治疗和结局的发现。
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不相关。
