Department of Physiology, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, China; Key laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, China.
First Affiliated Hospital, Jiamusi University, Jiamusi, Heilongjiang, China.
Biomed Pharmacother. 2023 Dec;168:115771. doi: 10.1016/j.biopha.2023.115771. Epub 2023 Oct 26.
Disco Interacting Protein 2 Homolog A (DIP2A) is expressed throughout the body and abundantly expressed in the brain tissue. It is activated by Follistatin-like 1 (FSTL1). Activated DIP2A interacts with several pathways, such as AMPK/mTOR and AKT pathways, to contribute to many biological processes, such as oxidative stress, transcriptional regulation, and apoptosis. Dysregulated DIP2A activation has been implicated in numerous processes in the brain. If the upstream pathways of DIP2A remain globally unexplored, many proteins, including cortactin, AMPK, and AKT, have been identified as its downstream targets in the literature. Recent studies have linked DIP2A to a variety of mechanisms in many types of brain disorders, suggesting that regulation of DIP2A could provide novel diagnostic and therapeutic approaches for brain disorders. In this review, we comprehensively summarized and discussed the current research on DIP2A in various brain disorders, such as stroke, autism spectrum disorders (ASD), Alzheimer's disease (AD), dyslexia, and glioma.
Disco Interacting Protein 2 Homolog A（DIP2A）在全身表达，并在脑组织中大量表达。它被 Follistatin-like 1（FSTL1）激活。激活的 DIP2A 与多个途径相互作用，如 AMPK/mTOR 和 AKT 途径，有助于许多生物学过程，如氧化应激、转录调节和细胞凋亡。DIP2A 激活的失调与大脑中的许多过程有关。如果 DIP2A 的上游途径仍未被广泛探索，许多蛋白质，包括 cortactin、AMPK 和 AKT，已被文献鉴定为其下游靶标。最近的研究将 DIP2A 与多种类型的脑疾病中的多种机制联系起来，表明 DIP2A 的调节可能为脑疾病提供新的诊断和治疗方法。在这篇综述中，我们全面总结和讨论了 DIP2A 在各种脑疾病中的研究进展，如中风、自闭症谱系障碍（ASD）、阿尔茨海默病（AD）、诵读困难和神经胶质瘤。
