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一种用于汞离子肉眼检测的罗丹明近红外探针及其应用。

A rhodamine NIR probe for naked eye detection of mercury ions and its application.

机构信息

Department of Chemistry and Material Science, College of Science, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, PR China.

Department of Chemistry and Material Science, College of Science, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, PR China.

出版信息

Spectrochim Acta A Mol Biomol Spectrosc. 2024 Feb 5;306:123553. doi: 10.1016/j.saa.2023.123553. Epub 2023 Oct 20.

Abstract

Fluorescence imaging technology has developed rapidly with its advantages, and near-infrared probes are worthy of attention because of their less background interference, low light damage, and infinite potential. Rhodamine and its derivatives have the unique structure of lactam helices, which is an ideal platform for the construction of on-off fluorescent sensors. In this paper, a novel near-infrared fluorescent probe (RBLS) based on rhodamine derivatives was synthesized for the transient detection of mercury ions. The closed-on structure can realize reversible sensor recovery by adding S. The superior imaging capability in living cells and in vivo in zebrafish holds promise for biological applications. In addition, the naked eye test strips prepared with RBLS probes can be used to detect and screen Hg in the environment and show good gradient change performance.

摘要

荧光成像技术具有其优势,发展迅速,近红外探针因其背景干扰较小、光损伤低和潜力无限而备受关注。罗丹明及其衍生物具有螺内酯环的独特结构,是构建开-关型荧光传感器的理想平台。本文基于罗丹明衍生物合成了一种新型的近红外荧光探针(RBLS),用于汞离子的瞬时检测。通过添加 S,闭环结构可以实现传感器的可逆恢复。在斑马鱼体内和活细胞中具有优越的成像能力,有望在生物应用中得到应用。此外,用 RBLS 探针制备的裸眼测试条可用于检测和筛选环境中的 Hg,显示出良好的梯度变化性能。

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