Department of Pain Management, The Second Hospital of Shandong University, Jinan, 250033, Shandong, China.
Sci Rep. 2023 Oct 28;13(1):18494. doi: 10.1038/s41598-023-45321-x.
The loss of hypocretin is thought to be the main pathophysiological mechanism of narcolepsy. There is strong evidence that hypocretin is related to the regulation of endocrine functions and depression. To explore thyroid hormone levels in narcolepsy patients was our aim. In addition, further is to analyze the relationship between thyroid hormone levels and sleep quality, anxiety, and depression in narcolepsy patients. There are 40 patients with narcolepsy and 40 healthy controls (HCs) were conducted. Blood samples were explored for thyroid function. Correlation analysis between thyroid hormones and clinical characteristics of narcolepsy was performed using Pearson or Spearman. Narcolepsy patients had significantly lower free thyroxine (FT) levels in comparison to controls (p < 0.001). No subject was diagnosed with primary hypothyroidism. There were 4 (10%) subjects with subclinical hypothyroidism. The serum FT4 levels were positively correlated with HAMA score (r = - 0.343, p = 0.030) by Pearson correlation analysis. The serum TSH levels and HAMD score (r = - 0.807 p ˂0.001), and ESS score (r = - 0.317, p = 0.046) both showed a negative correction. Hypocretin deficiency may be associated with the regulation of thyroid hormones in narcolepsy patients. The serum thyroid hormones may affect the severity and neuropsychological functions of narcolepsy patients.
下丘脑分泌素的缺失被认为是发作性睡病的主要病理生理学机制。有强有力的证据表明下丘脑分泌素与内分泌功能和抑郁的调节有关。我们旨在探讨发作性睡病患者的甲状腺激素水平。此外，进一步分析甲状腺激素水平与发作性睡病患者睡眠质量、焦虑和抑郁之间的关系。共纳入 40 例发作性睡病患者和 40 例健康对照者（HCs）。检测血样甲状腺功能。采用 Pearson 或 Spearman 检验分析甲状腺激素与发作性睡病临床特征的相关性。与对照组相比，发作性睡病患者的游离甲状腺素（FT）水平显著降低（p<0.001）。无一例患者被诊断为原发性甲状腺功能减退症。有 4 例（10%）患者为亚临床甲状腺功能减退症。Pearson 相关分析显示，血清 FT4 水平与 HAMA 评分呈正相关（r=-0.343，p=0.030）。血清 TSH 水平与 HAMD 评分（r=-0.807，p<0.001）和 ESS 评分（r=-0.317，p=0.046）呈负相关。下丘脑分泌素缺乏可能与发作性睡病患者甲状腺激素的调节有关。血清甲状腺激素可能影响发作性睡病患者的严重程度和神经心理功能。
