Department of Emergency, the First Hospital of Jilin University, Xinmin Street 1, Chaoyang District, Changchun, China.
Rehabilitation Department, the First Hospital of Jilin University, Changchun, China.
Sci Rep. 2023 Oct 28;13(1):18531. doi: 10.1038/s41598-023-45818-5.
The aim of this study was to investigate the relationship between serum level of hemoglobin and neurological outcomes following cardiac arrest. Relevant studies were identified by searching electronic databases including PubMed, Web of Science, Cochrane Library, and Embase from June 2012 through April 2023. Articles were rigorously reviewed for their study inclusion and exclusion criteria. Pooled effect date was determined using the standardized mean difference (SMD) and 95% confidence intervals (CI). The Newcastle-Ottawa Scale was used to evaluate study quality. Subgroup analyses were conducted to determine confounding factors affecting patient outcomes. Study heterogeneity, sensitivity, and publication bias were also determined.This meta-analysis included 11 studies involving 2519 patients. Our results suggest that high serum level of hemoglobin may improve neurological prognosis(SMD = 0.60, 95%CI = 0.49-0.71, I = 10.85). The findings of this study indicate that serum level of hemoglobin may be associated with better neurological prognosis, perhaps an appropriate increase in serum haemoglobin levels can improve the neurological prognosis of patients in cardiac arrest.
本研究旨在探讨心脏骤停后血清血红蛋白水平与神经功能结局之间的关系。通过检索 PubMed、Web of Science、Cochrane 图书馆和 Embase 等电子数据库，从 2012 年 6 月至 2023 年 4 月，确定了相关研究。严格按照纳入和排除标准对文章进行了审查。使用标准化均数差（SMD）和 95%置信区间（CI）来确定汇总效应数据。使用纽卡斯尔-渥太华量表评估研究质量。进行了亚组分析，以确定影响患者结局的混杂因素。还确定了研究异质性、敏感性和发表偏倚。这项荟萃分析包括 11 项涉及 2519 名患者的研究。我们的结果表明，高血清血红蛋白水平可能改善神经预后（SMD=0.60，95%CI=0.49-0.71，I=10.85）。本研究的结果表明，血清血红蛋白水平可能与更好的神经预后相关，或许适当增加血清血红蛋白水平可以改善心脏骤停患者的神经预后。
