Waindi E N, Gombe S, Oduor-Okelo D
Arch Androl. 1986;17(1):9-17. doi: 10.3109/01485018608986951.
Trypanosomiasis induces histological testicular degenerative changes leading to suppression of spermatogenesis in goats and laboratory animals. We present evidence associating these changes with trypanosome-induced endocrine dysfunction. Toggenburg goats were infected with approximately 100,000 trypanosomes. They were bled every 2 days, and the plasma testosterone was analyzed by radioimmunoassay. Testes were perfused with and fixed in Bouin's fixative for histological evaluation. The infected plasma samples showed depressed testosterone levels with episodic peaks reduced in both amplitude and frequency. Histological characteristics of the testicular and epididymal tissues revealed aspermic tubules and epididymides and desquamation of the tubular germinal epithelia. These testicular degenerative changes may be partly due to the depressed plasma testosterone levels.
锥虫病会引发组织学上的睾丸退行性变化，导致山羊和实验动物的精子发生受到抑制。我们提供了证据，将这些变化与锥虫诱导的内分泌功能障碍联系起来。托根堡山羊感染了大约100,000只锥虫。每两天对它们进行采血，并通过放射免疫分析法分析血浆睾酮。用布安氏固定液灌注并固定睾丸，以进行组织学评估。受感染的血浆样本显示睾酮水平降低，间歇性峰值的幅度和频率均降低。睾丸和附睾组织的组织学特征显示为无精子的小管和附睾，以及生精上皮的脱屑。这些睾丸退行性变化可能部分归因于血浆睾酮水平的降低。
