Zenkevich G S, Egorov V P, Shelkovaia I F
Arkh Patol. 1986;48(9):48-53.
On the basis of clinicomorphological study of 4 observations the authors outline a specific form of granulomatous encephalitis known from the literature as "reticulohistiocytic granulomatous encephalitis". The disease occurs at any age. Its course may be chronic or subacute, less frequently--acute. The process may localize anywhere, with predominant occurrence of the lesion in the periventricular region of the third ventricle. The morphological feature of this encephalitic form is a formation of large foci and microgranulomas from lymphocytes, histiocytes, macrophages, epithelioid cells and microgliacytes. The variants of granulomatous encephalitis distinguished by the ratio of the above-mentioned cellular elements should be considered as an etiologically heterogenic group of inflammatory brain diseases, that are likely to develop due to delayed hypersensitivity.
基于对4例病例的临床形态学研究,作者概述了一种文献中称为“网状组织细胞性肉芽肿性脑炎”的特殊形式的肉芽肿性脑炎。该疾病可发生于任何年龄。其病程可为慢性或亚急性,急性者较少见。病变可发生于任何部位,以第三脑室室周区域最为常见。这种脑炎形式的形态学特征是由淋巴细胞、组织细胞、巨噬细胞、上皮样细胞和小胶质细胞形成大的病灶和微肉芽肿。根据上述细胞成分比例区分的肉芽肿性脑炎变种应被视为一组病因异质性的炎性脑病,可能是由于迟发型超敏反应所致。