Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, Huddinge, Sweden.
Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
Clin Physiol Funct Imaging. 2024 Mar;44(2):171-178. doi: 10.1111/cpf.12863. Epub 2023 Nov 8.
Low-volume sprint exercise is likely to reduce body fat. Interleukin (IL-6) may mediate this by increasing adipose tissue (AT) lipolysis. Therefore, the exchange of AT IL-6 and glycerol, a marker of lipolysis, was examined in 10 healthy subjects performing three 30-s all-out sprints.
Blood samples were obtained from brachial artery (a) and a superficial subcutaneous vein (v) on the anterior abdominal wall up to 9 min after the last sprint and analysed for IL-6 and glycerol.
Arterial IL-6 increased 2-fold from rest to last sprint. AT venous IL-6 increased 15-fold from 0.4 ± 0.4 at rest to 7.0 ± 4 pg × mL (p < 0.0001) and AT v-a difference increased 45-fold from 0.12 ± 0.3 to 6.0 ± 5 pg x mL (p < 0.0001) 9 min after last sprint. Arterial glycerol increased 2.5-fold from rest to 9 min postsprint 1 (p < 0.0001) and was maintained during the exercise period. AT venous and v-a difference of glycerol increased 2-fold from rest to 9 min postsprint 1 (p < 0.0001 and p = 0.01, respectively), decreased until 18 min postsprint 2 (p < 0.001 and p < 0.0001), and then increased again until 9 min after last sprint (both p < 0.01).
The concurrent increase in venous IL-6 and glycerol in AT after last sprint is consistent with an IL-6 induced lipolysis in AT. Glycerol data also indicated an initial increase in lipolysis after sprint 1 that was unrelated to IL-6. Increased IL-6 in adipose tissue may, therefore, complement other sprint exercise-induced lipolytic agents.
低容量冲刺运动可能会减少体脂肪。白细胞介素 (IL-6) 可能通过增加脂肪组织 (AT) 的脂肪分解来介导这种作用。因此，在 10 名健康受试者进行三次 30 秒全力冲刺后，检查了 AT 白细胞介素 6 (IL-6) 和甘油的交换，甘油是脂肪分解的标志物。
在最后一次冲刺后，从肱动脉 (a) 和前腹壁的浅皮下静脉 (v) 采集血样，直到最后一次冲刺后 9 分钟，并分析白细胞介素 6 和甘油。
动脉白细胞介素 6 从休息时增加了 2 倍，达到最后一次冲刺时的 2 倍。AT 静脉白细胞介素 6 从休息时的 0.4±0.4 pg×mL 增加到 7.0±4 pg×mL（p<0.0001），AT v-a 差值增加了 45 倍，从 0.12±0.3 增加到 6.0±5 pg x mL（p<0.0001），最后一次冲刺后 9 分钟。动脉甘油从休息时增加了 2.5 倍，到第一次冲刺后 9 分钟时达到了 1（p<0.0001），并在运动期间保持不变。AT 静脉和 v-a 差异甘油从休息时增加了 2 倍，到第一次冲刺后 9 分钟（p<0.0001 和 p=0.01），然后下降到第二次冲刺后 18 分钟（p<0.001 和 p<0.0001），然后再次增加到最后一次冲刺后 9 分钟（均为 p<0.01）。
最后一次冲刺后，静脉白细胞介素 6 和甘油在 AT 中的同时增加与 IL-6 诱导的 AT 脂肪分解一致。甘油数据还表明，第一次冲刺后脂肪分解的初始增加与白细胞介素 6 无关。脂肪组织中白细胞介素 6 的增加可能会补充其他冲刺运动诱导的脂肪分解剂。
