Coelho J C, Gouma D J, Li Y F, Senninger N, Moody F G
Arq Gastroenterol. 1986 Jan-Mar;23(1):9-14.
The myoelectric activity of the sphincter of Oddi was studied both in the fasted and fed states and following administration of gastrointestinal hormones. Electromyographic recordings were obtained from 21 opossums in the fasted state and following administration of 20 Cal/kg of fat, protein, carbohydrate or isocaloric mixture of these three aliments. The proximal segment of the sphincter of Oddi generated spontaneous spike potentials that migrated to the distal segment of the sphincter. The frequency of spike potentials correlated with the migrating myoelectric complex in the duodenum. Following feeding, the migrating myoelectric complex was abolished and substituted by a fed pattern. The duration of the fed pattern and the frequency of spike potentials depended on the kind of aliment. Cholecystokinin and pentagastrin increased and glucagon and secretion decreased the frequency of spike potentials in the sphincter of Oddi. It is concluded from these studies that the sphincter of Oddi may play an important role in controlling the time and rate of biliary drainage into the duodenum.
在禁食和进食状态下以及给予胃肠激素后，对奥迪括约肌的肌电活动进行了研究。从21只处于禁食状态以及给予20千卡/千克脂肪、蛋白质、碳水化合物或这三种营养物质等热量混合物后的负鼠身上获取肌电图记录。奥迪括约肌的近端段产生自发的尖峰电位，并向括约肌的远端段迁移。尖峰电位的频率与十二指肠中的移行性肌电复合波相关。进食后，移行性肌电复合波消失，并被进食模式所取代。进食模式的持续时间和尖峰电位的频率取决于食物的种类。胆囊收缩素和五肽胃泌素增加，而胰高血糖素和分泌素降低奥迪括约肌中尖峰电位的频率。从这些研究得出结论，奥迪括约肌可能在控制胆汁排入十二指肠的时间和速率方面发挥重要作用。
