Coelho J C, Moody F G, Senninger N, Li Y F
Arch Surg. 1985 Sep;120(9):1060-4. doi: 10.1001/archsurg.1985.01390330070015.
Myoelectric activity of Oddi's sphincter and duodenum was correlated with common duct and pancreatic duct pressures in conscious opossums after infusion of the following substances: cholecystokinin, pentagastrin, glucagon, secretin, and acetylcholine. Cholecystokinin and pentagastrin increased and glucagon and secretin decreased the frequency of spike potentials in Oddi's sphincter and the duodenum. Acetylcholine was associated with the largest increase in spike potentials in both Oddi's sphincter and the duodenum. Although there was variation in the number of pressure elevations related to Oddi's sphincter spike potentials, the baseline pressure remained constant during administration of the hormones. Acetylcholine infusion increased the biliary and pancreatic pressures to 29 and 31 mm Hg, respectively. We conclude that gastrointestinal hormones may have an important role in regulating the excretion of bile and pancreatic juice into the duodenum.
在有意识的负鼠中，注入以下物质后，奥狄氏括约肌和十二指肠的肌电活动与胆总管和胰管压力相关：胆囊收缩素、五肽胃泌素、胰高血糖素、促胰液素和乙酰胆碱。胆囊收缩素和五肽胃泌素增加，而胰高血糖素和促胰液素降低奥狄氏括约肌和十二指肠的锋电位频率。乙酰胆碱与奥狄氏括约肌和十二指肠中锋电位的最大增加相关。尽管与奥狄氏括约肌锋电位相关的压力升高次数存在差异，但在激素给药期间基线压力保持恒定。注入乙酰胆碱分别使胆管和胰管压力升高至29和31毫米汞柱。我们得出结论，胃肠激素可能在调节胆汁和胰液排入十二指肠中起重要作用。
