大鼠心肌的肌温经济，慢性适应与急性变力作用

Myothermal economy of rat myocardium, chronic adaptation versus acute inotropism.

作者信息

Holubarsch C, Hasenfuss G, Blanchard E, Alpert N R, Mulieri L A, Just H

出版信息

Basic Res Cardiol. 1986;81 Suppl 1:95-102. doi: 10.1007/978-3-662-11374-5_10.

Abstract

By means of rapid planar Hill type antimony-bismuth thermophiles the initial heat liberated by papillary muscles was measured synchronously with developed tension for control (C), pressure-overload (GOP), and hypothyrotic (PTU) rat myocardium (chronic experiments) and after application of 10(-6) M isoproterenol or 200 10(-6) M UDCG-115. Economy of force production was analyzed by the ratio of initial heat versus developed tension-time integral. This ratio was found to be reduced by 34% in GOP and by 43% in PTU myocardium (P less than 0.01, respectively) indicating increased economy of force production. In contrast, isoproterenol increased initial heat versus tension-time integral by 70% (P less than 0.01) indicating reduced economy of force production. No change in this ratio was found for UDCG-115. The presented data indicates that long and short term modulation of myocardial energetic costs of force generation is possible. The basic mechanisms for these myocardial alterations are discussed.

摘要

通过快速平面希尔型锑 - 铋嗜热菌，同步测量了对照（C）、压力超负荷（GOP）和甲状腺功能减退（PTU）大鼠心肌乳头肌释放的初始热量与所产生的张力（慢性实验），以及在应用10⁻⁶ M异丙肾上腺素或200×10⁻⁶ M UDCG - 115之后的情况。通过初始热量与所产生张力 - 时间积分的比值分析了力产生的经济性。发现该比值在GOP心肌中降低了34%，在PTU心肌中降低了43%（分别为P < 0.01），表明力产生的经济性增加。相比之下，异丙肾上腺素使初始热量与张力 - 时间积分增加了70%（P < 0.01），表明力产生的经济性降低。未发现UDCG - 115对此比值有影响。所呈现的数据表明，心肌产生力的能量消耗的长期和短期调节是可能的。讨论了这些心肌改变的基本机制。