Babkoff Aryeh, Berner-Wygoda Yael, Diment Judith, Kustanovich Anatoli, Zick Aviad, Katz Daniela, Grinshpun Albert
Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Case Rep Oncol. 2023 Sep 19;16(1):954-962. doi: 10.1159/000533519. eCollection 2023 Jan-Dec.
Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC-rearranged sarcoma. Within this group, CIC-FOXO4 translocation is an exceedingly rare fusion that has been reported only 4 times in the literature. Herein, we report in-depth the pathological, clinical, and molecular features of a CIC-FOXO4 translocation-driven tumor in a 46-year-old woman.
小圆细胞肉瘤是一组起源于骨骼和软组织的未分化恶性肿瘤，尤指尤文肉瘤。最近，世界卫生组织引入了一种新的分类方法，其中包括这些肉瘤的一个额外亚组，称为CIC重排肉瘤。在这一组中，CIC-FOXO4易位是一种极其罕见的融合，在文献中仅报道过4次。在此，我们深入报告了一名46岁女性中由CIC-FOXO4易位驱动的肿瘤的病理、临床和分子特征。
