短头阻塞性气道综合征手术治疗对法国斗牛犬运动体温调节反应的影响：一项初步研究。

The effect of the surgical treatment of brachycephalic obstructive airway syndrome on the thermoregulatory response to exercise in French bulldogs: a pilot study.

作者信息

Žgank Žiga, Nemec Svete Alenka, Lenasi Helena, Vodičar Janez, Erjavec Vladimira

机构信息

Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.

Faculty of Medicine, Institute of Physiology, University of Ljubljana, Ljubljana, Slovenia.

出版信息

Front Vet Sci. 2023 Oct 12;10:1229687. doi: 10.3389/fvets.2023.1229687. eCollection 2023.

DOI:10.3389/fvets.2023.1229687

PMID:37901097

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10601647/

Abstract

INTRODUCTION

Due to altered anatomy of the upper respiratory tract, brachycephalic dogs exhibit increased airway resistance and reduced surface area for evaporative heat loss, predisposing them to respiratory and thermoregulatory problems, a syndrome referred to as Brachycephalic Obstructive Airway Syndrome (BOAS). Compared to non-brachycephalic dogs, brachycephalic breeds are more susceptible to heat-related injuries even at low ambient temperatures and relatively low physical activity levels. Surgical treatment alleviates clinical signs, potentially improving dogs' thermoregulatory ability with BOAS. Our study aimed to investigate the thermoregulatory response in French bulldogs before and after the surgical correction of BOAS, respectively.

METHODS

Thirteen dogs were exposed to dynamic exercise on a treadmill and the dynamics of their rectal temperature (RT) and heart rate (HR) was measured. The experiment was performed in two independent sessions, before and after the surgical treatment. The test consisted of two consecutive 5-min walks at a speed of 2.5 km/h, first at an inclination of 0% and the second at an inclination of 5%, and a 30-min recovery period. Rectal temperature and HR were measured before the start of the test (t0), at the end of the first (t1) and the second part (t2), and 15 min (t3) and 30 min (t4) in the recovery.

RESULTS

A significant increase in RT and HR was observed during exercise and recovery compared to the resting values, implying that the exercise intensity was sufficient to challenge the thermoregulatory response. The increase of RT was significantly lower during both parts (t1: = 0.004; t2: < 0.001) of exercise after the surgical treatment than before the treatment. Although a trend of lower RT after recovery was observed compared to before the surgery, it did not reach statistical significance. Similarly to RT, the HR was significantly lower during exercise after the first ( = 0.020) and the second part ( = 0.011) of exercise after the surgery compared to before the surgery but did not reach significance in the recovery.

CONCLUSION

Surgical treatment of BOAS can improve thermoregulation during exercise in French bulldogs with BOAS.

摘要

引言

由于上呼吸道解剖结构改变，短头犬气道阻力增加，蒸发散热表面积减小，易出现呼吸和体温调节问题，即短头阻塞性气道综合征（BOAS）。与非短头犬相比，即使在环境温度较低且身体活动水平相对较低的情况下，短头犬品种也更容易受到热相关损伤。手术治疗可缓解临床症状，可能改善患有BOAS的犬的体温调节能力。我们的研究旨在分别调查法国斗牛犬在BOAS手术矫正前后的体温调节反应。

方法

13只犬在跑步机上进行动态运动，并测量其直肠温度（RT）和心率（HR）的动态变化。实验在手术治疗前后两个独立阶段进行。测试包括以2.5公里/小时的速度连续进行两次5分钟的步行，第一次倾斜度为0%，第二次倾斜度为5%，以及30分钟的恢复期。在测试开始前（t0）、第一部分（t1）和第二部分（t2）结束时以及恢复期的15分钟（t3）和30分钟（t4）测量直肠温度和HR。

结果

与静息值相比，运动和恢复期间观察到RT和HR显著增加，这意味着运动强度足以挑战体温调节反应。手术治疗后运动的两个阶段（t1：P = 0.004；t2：P < 0.001）期间RT的升高明显低于治疗前。尽管与手术前相比，恢复后观察到RT有降低趋势，但未达到统计学意义。与RT类似，手术后运动的第一部分（P = 0.020）和第二部分（P = 0.011）期间HR明显低于手术前，但在恢复期间未达到显著差异。